Relationship between plasma concentrations of the l-enantiomer of methadone and response to methadone maintenance treatment

This study evaluated the relationship between the plasma concentration of l-methadone and response to methadone in real-world patients, in order to identify a minimum plasma concentration above which methadone treatment is effective. Ninety-four patients with opioid dependence under maintenance meth...

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Bibliographic Details
Published in:European journal of pharmacology 2015-08, Vol.760, p.1-6
Main Authors: Meini, Milo, Moncini, Marco, Daini, Laura, Giarratana, Tania, Scaramelli, Daniela, Chericoni, Silvio, Stefanelli, Fabio, Rucci, Paola
Format: Article
Language:English
Subjects:
Adult
Cross-Sectional Studies
Heroin Dependence - blood
Heroin Dependence - diagnosis
Heroin Dependence - drug therapy
Humans
Maintenance treatment
Methadone
Methadone - blood
Methadone - chemistry
Methadone - therapeutic use
Middle Aged
Opiate Substitution Treatment - methods
Opioid-Related Disorders - blood
Opioid-Related Disorders - diagnosis
Opioid-Related Disorders - drug therapy
Plasma methadone concentration
Stereoisomerism
Treatment Outcome
Young Adult
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Summary:This study evaluated the relationship between the plasma concentration of l-methadone and response to methadone in real-world patients, in order to identify a minimum plasma concentration above which methadone treatment is effective. Ninety-four patients with opioid dependence under maintenance methadone treatment were consecutively recruited. Response was defined as negative urine analyses in the three weeks prior to the blood sampling. The percentage of participants with a plasma l-methadone concentration between 100 and 250ng/ml was 54.2% among those with a methadone dosage ≥60mg/day. Plasma l-methadone concentrations were significantly higher in patients with negative urine analyses compared with those with positive urine analyses (median 93 vs. 77ng/ml, Mann–Whitney test, P
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2015.03.081