Impaired sleep-associated modulation of post-exercise corticomotor depression in multiple sclerosis

Abstract Objective To compare the beneficial effect of nap versus rest on the recovery of motor evoked potentials (MEPs) after a fatiguing exercise performed in patients with multiple sclerosis (MS) and healthy controls. Methods In 12 MS patients and 12 healthy controls, MEPs were recorded from the...

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Bibliographic Details
Published in:Journal of the neurological sciences 2015-07, Vol.354 (1), p.91-96
Main Authors: Bridoux, Agathe, Créange, Alain, Sangare, Aude, Ayache, Samar S, Hosseini, Hassan, Drouot, Xavier, Lefaucheur, Jean-Pascal
Format: Article
Language:English
Subjects:
Adult
Cortical Spreading Depression - physiology
Evoked Potentials, Motor - physiology
Exercise
Exercise - physiology
Fatigue
Female
Humans
Male
Middle Aged
Motor Cortex - physiology
Motor evoked potentials
Multiple sclerosis
Multiple Sclerosis - diagnosis
Multiple Sclerosis - physiopathology
Neurology
Polysomnography
Sleep
Sleep - physiology
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Summary:Abstract Objective To compare the beneficial effect of nap versus rest on the recovery of motor evoked potentials (MEPs) after a fatiguing exercise performed in patients with multiple sclerosis (MS) and healthy controls. Methods In 12 MS patients and 12 healthy controls, MEPs were recorded from the adductor pollicis muscle before, 10 and 60 min (T0, T10, and T60) after an effort of thumb adduction at 25% of maximal voluntary contraction force for 24 min. After the effort, the subject was maintained at rest or invited to have a nap while monitored with polysomnography. The two sessions (nap and rest) were randomly performed in each subject during the same day. The impact of nap and rest on post-exercise changes in MEP amplitude were studied in each group (patients and controls) and then compared between the two groups. Results Although MEP amplitude at baseline was lower in MS patients than in controls, post-exercise corticomotor depression (PECD), expressed as T10/T0 MEP amplitude ratio, was similar in both groups. Regarding MEP amplitude recovery at T60, nap was significantly more beneficial than rest in healthy subjects, but not in MS patients. Conclusion Motor recovery from PECD following a fatiguing exercise can be enhanced by sleep (at least a short nap) in healthy subjects. In MS patients, sleep restorative effect is reduced or lost, maybe contributing to the excessive fatigue or fatigability characterized in these patients.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2015.05.006