Prereproductive stress in adolescent female rats affects behavior and corticosterone levels in second-generation offspring

Highlights • We ask whether prereproductive stress (PRS) to female rats affects F2 progeny. • PRS in adolescence led to reduced anxiety and enhanced fear learning in F2. • PRS also led to sex-dependent changes in corticosterone across three generations. • Stress leads to adaptive behavior in second-...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2015-08, Vol.58, p.120-129
Main Authors: Zaidan, Hiba, Gaisler-Salomon, Inna
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Behavior
Behavior, Animal - physiology
Corticosterone
Corticosterone - blood
Endocrinology & Metabolism
Female
Hypothalamo-Hypophyseal System - physiopathology
Male
Pituitary-Adrenal System - physiopathology
Pregnancy
Prenatal Exposure Delayed Effects - blood
Prenatal Exposure Delayed Effects - physiopathology
Psychiatry
Rat
Rats
Rats, Sprague-Dawley
Sex differences
Stress
Stress, Psychological - blood
Stress, Psychological - physiopathology
Transgenerational
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Summary:Highlights • We ask whether prereproductive stress (PRS) to female rats affects F2 progeny. • PRS in adolescence led to reduced anxiety and enhanced fear learning in F2. • PRS also led to sex-dependent changes in corticosterone across three generations. • Stress leads to adaptive behavior in second-generation progeny. • Adolescent stress transgenerationally affects behavior and neuroendocrine function.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.04.013