Vascular function and ocular involvement in sarcoidosis

Ocular involvement occurs in sarcoidosis (Sar) patients mainly in the form of uveitis. This study was designed to determine if uveitis in Sar patients is associated with vascular impairment. We enrolled 82 Sar patients and 77, age and sex matched, control subjects (Cl). Sar patients were divided int...

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Bibliographic Details
Published in:Microvascular research 2015-07, Vol.100, p.54-58
Main Authors: Siasos, Gerasimos, Paraskevopoulos, Theodoros, Gialafos, Elias, Rapti, Aggeliki, Oikonomou, Evangelos, Zaromitidou, Marina, Mourouzis, Konstantinos, Siasou, Georgia, Gouliopoulos, Nikolaos, Tsalamandris, Sotiris, Vlasis, Konstantinos, Stefanadis, Christodoulos, Papavassiliou, Athanasios G., Tousoulis, Dimitris
Format: Article
Language:English
Subjects:
Arterial stiffness
Atherosclerosis
Brachial Artery - diagnostic imaging
Brachial Artery - physiopathology
Case-Control Studies
Endothelial function
Endothelium, Vascular - diagnostic imaging
Endothelium, Vascular - physiopathology
Humans
Ocular sarcoidosis
Predictive Value of Tests
Prognosis
Pulse Wave Analysis
Sarcoidosis - complications
Sarcoidosis - diagnosis
Ultrasonography
Uveitis
Uveitis - diagnosis
Uveitis - etiology
Uveitis - physiopathology
Vascular Diseases - diagnosis
Vascular Diseases - etiology
Vascular Diseases - physiopathology
Vascular Endothelium
Vascular Stiffness
Vasodilation
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Summary:Ocular involvement occurs in sarcoidosis (Sar) patients mainly in the form of uveitis. This study was designed to determine if uveitis in Sar patients is associated with vascular impairment. We enrolled 82 Sar patients and 77, age and sex matched, control subjects (Cl). Sar patients were divided into those with ocular sarcoidosis (OS) and those without ocular sarcoidosis (WOS). Endothelial function was evaluated by flow-mediated dilation (FMD). Pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections. Although there was no significant difference in sex, age and mean arterial pressure, patients with OS compared to WOS patients and Cl subjects had impaired FMD (p
ISSN:0026-2862
1095-9319
DOI:10.1016/j.mvr.2015.03.008