Effect of LPS treatment on the viability and chemokine synthesis by epithelial cells and gingival fibroblasts

Highlights • The effect of prolonged contact with lipopolysaccharide (LPS) on oral mucosal cells was evaluated. • Prolonged LPS contact was used to simulate a prolonged inflammatory stimulus. • Prolonged LPS contact with oral mucosal cells negatively influenced cell functions. • Prolonged LPS contac...

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Bibliographic Details
Published in:Archives of oral biology 2015-08, Vol.60 (8), p.1117-1121
Main Authors: Basso, F.G, Soares, D.G, Pansani, T.N, Turrioni, A.P.S, Scheffel, D.L, de Souza Costa, C.A, Hebling, J
Format: Article
Language:English
Subjects:
Advanced Basic Science
Cell Count
Cell Line
Cell Survival - drug effects
Cells, Cultured
Chemokines - biosynthesis
Dentistry
Enzyme-Linked Immunosorbent Assay
Epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - secretion
Fibroblasts
Fibroblasts - drug effects
Fibroblasts - secretion
Gingiva - cytology
Gingiva - metabolism
Humans
Inflammation
Lipopolysaccharides - pharmacology
Wound healing
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Summary:Highlights • The effect of prolonged contact with lipopolysaccharide (LPS) on oral mucosal cells was evaluated. • Prolonged LPS contact was used to simulate a prolonged inflammatory stimulus. • Prolonged LPS contact with oral mucosal cells negatively influenced cell functions. • Prolonged LPS contact can decrease the viability of oral mucosal cells. • Prolonged LPS contact increased the chemokine expression of oral mucosal cells.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.04.010