Overexpression of Endothelin-1 Leads to More Severe Pulmonary Complex Vascular Lesions Associated with the Human Immunodeficiency Virus

Background and Aims Despite increase in survival of HIV patients due to highly active antiretroviral therapy (HAART), non-infectious complications are still prevalent such as presentation of lung vasculopathy, even in asymptomatic patients. Endothelin-1 (ET-1) is a potent vasoconstrictor that causes...

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Bibliographic Details
Published in:Archives of medical research 2015-04, Vol.46 (3), p.228-232
Main Authors: Sandoval-Gutierrez, Jose Luis, Rodriguez-Silverio, Juan, Rivera-Rosales, Rosa Maria, Sevilla-Reyes, Edgar, Flores-Murrieta, Francisco Javier, Rojas-Serrano, Jorge, Reyes-Teran, Gustavo
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
Adult
Endothelin
Endothelin-1 - biosynthesis
Female
Human immunodeficiency virus
Humans
Internal Medicine
Lung - blood supply
Lung - metabolism
Lung - pathology
Lung Diseases - etiology
Lung Diseases - metabolism
Lung Diseases - physiopathology
Male
Middle Aged
Pulmonary Artery - pathology
Pulmonary Circulation
Vascular Diseases - etiology
Vascular Diseases - metabolism
Vascular Diseases - physiopathology
Young Adult
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Summary:Background and Aims Despite increase in survival of HIV patients due to highly active antiretroviral therapy (HAART), non-infectious complications are still prevalent such as presentation of lung vasculopathy, even in asymptomatic patients. Endothelin-1 (ET-1) is a potent vasoconstrictor that causes pulmonary vasculopathy. Participation of this protein in the pulmonary circulation in HIV patients has not been elucidated. In this work we studied the presence and expression of ET-1 in pulmonary complex vascular lesions associated with human immunodeficiency virus (PCVL/HIV). Methods We used immunohistochemistry and immunochemiluminescence (imagej) to determine the different degrees of expression of ET-1 in PCVL/HIV in comparison with non-PCVL/HIV. Reagents used were anti-endothelin-1 and an automated system. All data are presented as mean and standard deviation (SD). Differences were analyzed with one-way ANOVA; p
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2015.04.002