Usefulness of Neutrophil/Lymphocyte Ratio as a Predictor of Atrial Fibrillation: A Meta-analysis

Background and Aims Current evidence suggests that a high neutrophil/lymphocyte ratio (NLR) may increase the risk of atrial fibrillation (AF), but this association is still uncertain. The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF....

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Published in:Archives of medical research 2015-04, Vol.46 (3), p.199-206
Main Authors: Shao, Qingmiao, Chen, Kangyin, Rha, Seung-Woon, Lim, Hong-Euy, Li, Guangping, Liu, Tong
Format: Article
Language:English
Subjects:
Atrial fibrillation
Atrial Fibrillation - blood
Humans
Inflammation
Internal Medicine
Leukocyte Count
Lymphocyte Count
Lymphocytes
Marker
Meta-analysis
Neutrophil/lymphocyte ratio
Neutrophils
Predictive Value of Tests
Risk Factors
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container_start_page 199
container_title Archives of medical research
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creator Shao, Qingmiao
Chen, Kangyin
Rha, Seung-Woon
Lim, Hong-Euy
Li, Guangping
Liu, Tong
description Background and Aims Current evidence suggests that a high neutrophil/lymphocyte ratio (NLR) may increase the risk of atrial fibrillation (AF), but this association is still uncertain. The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF. Methods We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I2 >50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95% confidence interval [CI] 1.16–1.35) with significant heterogeneity across studies ( I2  = 82.7%, p  
doi_str_mv 10.1016/j.arcmed.2015.03.011
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The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF. Methods We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I2 &gt;50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95% confidence interval [CI] 1.16–1.35) with significant heterogeneity across studies ( I2  = 82.7%, p  &lt;0.01) and for the post-NLR level (following CABG, RFCA and cardioversion) was 1.518 (95% CI 1.076–2.142) with significant heterogeneity across studies ( I2  = 93.7%, p  = 0.017). We also showed an association between AF recurrence following CABG, RFCA and cardioversion and baseline NLR level (OR 1.517, 95% CI 1.108–2.079) with significant heterogeneity across studies ( I2  = 86.8%, p  &lt;0.01). Conclusions Our comprehensive meta-analysis suggests that the high level of NLR, whether baseline or postsurgery/procedure, is associated with the increased risk of AF recurrence/occurrence.</description><identifier>ISSN: 0188-4409</identifier><identifier>EISSN: 1873-5487</identifier><identifier>DOI: 10.1016/j.arcmed.2015.03.011</identifier><identifier>PMID: 25980945</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Atrial fibrillation ; Atrial Fibrillation - blood ; Humans ; Inflammation ; Internal Medicine ; Leukocyte Count ; Lymphocyte Count ; Lymphocytes ; Marker ; Meta-analysis ; Neutrophil/lymphocyte ratio ; Neutrophils ; Predictive Value of Tests ; Risk Factors</subject><ispartof>Archives of medical research, 2015-04, Vol.46 (3), p.199-206</ispartof><rights>IMSS</rights><rights>2015 IMSS</rights><rights>Copyright © 2015 IMSS. Published by Elsevier Inc. 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The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF. Methods We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I2 &gt;50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95% confidence interval [CI] 1.16–1.35) with significant heterogeneity across studies ( I2  = 82.7%, p  &lt;0.01) and for the post-NLR level (following CABG, RFCA and cardioversion) was 1.518 (95% CI 1.076–2.142) with significant heterogeneity across studies ( I2  = 93.7%, p  = 0.017). We also showed an association between AF recurrence following CABG, RFCA and cardioversion and baseline NLR level (OR 1.517, 95% CI 1.108–2.079) with significant heterogeneity across studies ( I2  = 86.8%, p  &lt;0.01). 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The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF. Methods We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I2 &gt;50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95% confidence interval [CI] 1.16–1.35) with significant heterogeneity across studies ( I2  = 82.7%, p  &lt;0.01) and for the post-NLR level (following CABG, RFCA and cardioversion) was 1.518 (95% CI 1.076–2.142) with significant heterogeneity across studies ( I2  = 93.7%, p  = 0.017). We also showed an association between AF recurrence following CABG, RFCA and cardioversion and baseline NLR level (OR 1.517, 95% CI 1.108–2.079) with significant heterogeneity across studies ( I2  = 86.8%, p  &lt;0.01). Conclusions Our comprehensive meta-analysis suggests that the high level of NLR, whether baseline or postsurgery/procedure, is associated with the increased risk of AF recurrence/occurrence.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25980945</pmid><doi>10.1016/j.arcmed.2015.03.011</doi><tpages>8</tpages></addata></record>
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subjects Atrial fibrillation
Atrial Fibrillation - blood
Humans
Inflammation
Internal Medicine
Leukocyte Count
Lymphocyte Count
Lymphocytes
Marker
Meta-analysis
Neutrophil/lymphocyte ratio
Neutrophils
Predictive Value of Tests
Risk Factors
title Usefulness of Neutrophil/Lymphocyte Ratio as a Predictor of Atrial Fibrillation: A Meta-analysis
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