Transformation of alpha‐santonin via two independent pathways by Pseudomonas strain S ATCC 43388

Pseudomonas strain S (ATCC 43388) transforms alpha‐santonin in the presence of dicyclohexylcarbodiimide (DCCD) to 1,2‐dihydrosantonin (DHS) and two more products, D1 and D2. D2 was identified as 4,5‐dihydroxysantonin (DHXS). Cells incubated with semicarbazide (SC) formed DHXS but not DHS. Simultaneo...

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Bibliographic Details
Published in:Letters in applied microbiology 1993-11, Vol.17 (5), p.212-214
Main Authors: Colaco, D., Furtado, I., Naik, U. P., Mavinkurve, S., Paknikar, S. K.
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Pseudomonas
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Summary:Pseudomonas strain S (ATCC 43388) transforms alpha‐santonin in the presence of dicyclohexylcarbodiimide (DCCD) to 1,2‐dihydrosantonin (DHS) and two more products, D1 and D2. D2 was identified as 4,5‐dihydroxysantonin (DHXS). Cells incubated with semicarbazide (SC) formed DHXS but not DHS. Simultaneous formation of DHS and DHXS is indicative of the presence of two distinct pathways of alpha‐santonin biotransformation.
ISSN:0266-8254
1472-765X
DOI:10.1111/j.1472-765X.1993.tb01449.x