Carbon tetrachloride-induced liver injury in mice is tissue factor dependent

Highlights • Our study test the hypothesis that coagulation system (especially tissue factor) responsible for liver injury. • Hepatic toxicity confirmed as deposition of tissue factor (TF) and fibrin around central vein. • Tissue factor antisense (TF-AS) significantly prevents toxicity induced by CC...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-05, Vol.39 (3), p.1199-1205
Main Authors: Abdel-Bakky, M.S, Helal, G.K, El-Sayed, E.M, Saad, A.S
Format: Article
Language:English
Subjects:
Animals
Carbon Tetrachloride - toxicity
CCl4
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - metabolism
Chemical and Drug Induced Liver Injury - pathology
Disease Models, Animal
DNA, Antisense - administration & dosage
DNA, Antisense - pharmacology
Emergency
Fibrin
Fibrin - metabolism
Gene Expression Regulation, Enzymologic - drug effects
Glutathione - metabolism
Liver injury
Male
Mice
Oligonucleotide
Thromboplastin - antagonists & inhibitors
Thromboplastin - metabolism
Tissue factor antisense
Transaminases - blood
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Summary:Highlights • Our study test the hypothesis that coagulation system (especially tissue factor) responsible for liver injury. • Hepatic toxicity confirmed as deposition of tissue factor (TF) and fibrin around central vein. • Tissue factor antisense (TF-AS) significantly prevents toxicity induced by CCl4. • Administration of TF-AS appears to be an effective and promising method for the prevention of liver injury.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.02.012