Dysosesquiflorins A and B, sesquiterpenoids from Dysoxylum densiflorum

Two new aromadendrane sesquiterpenoids, dysosesquiflorins A and B ( 1 and 2 ), were isolated from Dysoxylum densiflorum bark, and their structures were elucidated on the basis of NMR spectroscopic data. These dysosesquiflorins showed in vitro cytotoxic activity against several cancer cell lines.

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Bibliographic Details
Published in:Journal of natural medicines 2015-07, Vol.69 (3), p.411-415
Main Authors: Nugroho, Alfarius E., Sugiura, Rio, Momota, Takanori, Hirasawa, Yusuke, Wong, Chin Piow, Kaneda, Toshio, Hadi, A. Hamid A., Morita, Hiroshi
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Inhibitory Concentration 50
MCF-7 Cells
Medicinal Chemistry
Meliaceae - chemistry
Molecular Structure
Pharmacology/Toxicology
Pharmacy
Plant Sciences
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
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Summary:Two new aromadendrane sesquiterpenoids, dysosesquiflorins A and B ( 1 and 2 ), were isolated from Dysoxylum densiflorum bark, and their structures were elucidated on the basis of NMR spectroscopic data. These dysosesquiflorins showed in vitro cytotoxic activity against several cancer cell lines.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-015-0888-6