Serum bromide concentrations following loading dose in epileptic dogs

OBJECTIVE: To determine serum bromide concentrations following an oral loading dose in dogs. METHODS: Retrospective review of clinical records of dogs suffering from seizures that were treated with bromide. A loading dose of 600 mg/kg potassium bromide was administered orally in 17 to 48 hours toget...

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Bibliographic Details
Published in:Journal of small animal practice 2014-02, Vol.55 (2), p.108-111
Main Authors: Gindiciosi, B, Palus, V, Eminaga, S, Villiers, E, Bruto Cherubini, G
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anticonvulsants - administration & dosage
Anticonvulsants - blood
Anticonvulsants - therapeutic use
blood
body weight
Bromides - administration & dosage
Bromides - blood
Bromides - therapeutic use
colorimetry
Dog Diseases - blood
Dog Diseases - drug therapy
Dogs
Epilepsy - blood
Epilepsy - drug therapy
Epilepsy - veterinary
gold
oral administration
potassium bromide
Potassium Compounds - administration & dosage
Potassium Compounds - blood
Potassium Compounds - therapeutic use
Retrospective Studies
seizures
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Summary:OBJECTIVE: To determine serum bromide concentrations following an oral loading dose in dogs. METHODS: Retrospective review of clinical records of dogs suffering from seizures that were treated with bromide. A loading dose of 600 mg/kg potassium bromide was administered orally in 17 to 48 hours together with a maintenance dose of 30 mg/kg/day. Blood samples were collected within 24 hours after completing the protocol and serum bromide concentrations were determined by ultra‐violet gold chloride colorimetric assay. RESULTS: Thirty‐eight dogs were included in the study. The median age was 3 (range, 0 · 2 to 10) years and bodyweight 21 · 8 (3 · 45 to 46 · 2) kg. The median serum bromide concentration was 1 · 26 (0 · 74 to 3 · 6) mg/mL. Thirty‐two dogs (84 · 2%) had serum bromide concentrations within the therapeutic interval (1 to 3 mg/mL). The serum concentration in five dogs (13 · 2%) was just under the minimal therapeutic value and in one dog (2 · 6%) it exceeded the maximal therapeutic value (3 · 6 mg/mL). CLINICAL RELEVANCE: Following this oral loading dose protocol, serum bromide concentrations reach the therapeutic range in the majority of dogs. This indicates that the suggested protocol is effective in achieving therapeutic concentrations rapidly in epileptic dogs.
ISSN:0022-4510
1748-5827
DOI:10.1111/jsap.12173