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Patterns of Weight Loss Response Following Gastric Bypass and Sleeve Gastrectomy

Background Despite the health benefits of bariatric surgery (BS) extend beyond WL, better understanding of the WL response may help improve the outcomes of BS. In this context, we aimed to assess patterns within the variability of weight loss (WL) after Roux-en-Y gastric bypass (RYGB) and sleeve gas...

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Published in:Obesity surgery 2015-07, Vol.25 (7), p.1177-1183
Main Authors: de Hollanda, Ana, Ruiz, Tania, Jiménez, Amanda, Flores, Lílliam, Lacy, Antonio, Vidal, Josep
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cited_by cdi_FETCH-LOGICAL-c442t-5eead4e508ef16c84f96acefff4c67dbcd4dde1c66ca5f4fba964fb71b1169c03
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container_title Obesity surgery
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creator de Hollanda, Ana
Ruiz, Tania
Jiménez, Amanda
Flores, Lílliam
Lacy, Antonio
Vidal, Josep
description Background Despite the health benefits of bariatric surgery (BS) extend beyond WL, better understanding of the WL response may help improve the outcomes of BS. In this context, we aimed to assess patterns within the variability of weight loss (WL) after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Methods WL data from 658 subjects that underwent RYGB ( n  = 464) or SG ( n  = 194) as first BS were analyzed. Based on excess WL (EWL), subjects were categorized as good WL responders (EWL ≥ 50 % at nadir weight and throughout follow-up), primarily poor WL responders (1-PWL:EWL 
doi_str_mv 10.1007/s11695-014-1512-7
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In this context, we aimed to assess patterns within the variability of weight loss (WL) after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Methods WL data from 658 subjects that underwent RYGB ( n  = 464) or SG ( n  = 194) as first BS were analyzed. Based on excess WL (EWL), subjects were categorized as good WL responders (EWL ≥ 50 % at nadir weight and throughout follow-up), primarily poor WL responders (1-PWL:EWL &lt; 50 % at nadir weight and thereafter), and secondarily poor WL responders (2-PWL:EWL ≥ 50 % at nadir weight, but &lt;50 % at last follow-up visit). Predictors associated with different WL outcomes were ascertained using regression analysis. Results Median follow-up was 55.7 months. Nadir EWL ranged 12.4–143.6 %; last follow-up visit EWL ranged −22.1–143.6 % and weight regain (WR) ranged 0–64.1 kg. Good WL was found in 75.7 of the cohort. 1-PWL response (4.7 %) was characterized by lesser WL but similar WR as compared to good WL and was associated with larger BMI and diabetes prior to surgery. 2-PWL response (19.6 %) was characterized by larger WR as compared to the other groups and was more common following SG. Lesser percentage of medical appointments kept was associated with 1-PWL and 2-PWL. Conclusion Our data show the high inter-individual variability of the WL response at mid-term after RYGB and SG and that poor WL after BS could be illustrated by two different patterns, characterized either by sustained limited WL (1-PWL), or pronounced weight regain (2-PWL).</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-014-1512-7</identifier><identifier>PMID: 25421881</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Female ; Gastrectomy ; Gastric Bypass ; Gastrointestinal surgery ; Humans ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Obesity ; Obesity, Morbid - physiopathology ; Obesity, Morbid - surgery ; Original Contributions ; Surgery ; Treatment Outcome ; Weight control ; Weight Loss - physiology</subject><ispartof>Obesity surgery, 2015-07, Vol.25 (7), p.1177-1183</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-5eead4e508ef16c84f96acefff4c67dbcd4dde1c66ca5f4fba964fb71b1169c03</citedby><cites>FETCH-LOGICAL-c442t-5eead4e508ef16c84f96acefff4c67dbcd4dde1c66ca5f4fba964fb71b1169c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25421881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Hollanda, Ana</creatorcontrib><creatorcontrib>Ruiz, Tania</creatorcontrib><creatorcontrib>Jiménez, Amanda</creatorcontrib><creatorcontrib>Flores, Lílliam</creatorcontrib><creatorcontrib>Lacy, Antonio</creatorcontrib><creatorcontrib>Vidal, Josep</creatorcontrib><title>Patterns of Weight Loss Response Following Gastric Bypass and Sleeve Gastrectomy</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background Despite the health benefits of bariatric surgery (BS) extend beyond WL, better understanding of the WL response may help improve the outcomes of BS. In this context, we aimed to assess patterns within the variability of weight loss (WL) after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Methods WL data from 658 subjects that underwent RYGB ( n  = 464) or SG ( n  = 194) as first BS were analyzed. Based on excess WL (EWL), subjects were categorized as good WL responders (EWL ≥ 50 % at nadir weight and throughout follow-up), primarily poor WL responders (1-PWL:EWL &lt; 50 % at nadir weight and thereafter), and secondarily poor WL responders (2-PWL:EWL ≥ 50 % at nadir weight, but &lt;50 % at last follow-up visit). Predictors associated with different WL outcomes were ascertained using regression analysis. Results Median follow-up was 55.7 months. Nadir EWL ranged 12.4–143.6 %; last follow-up visit EWL ranged −22.1–143.6 % and weight regain (WR) ranged 0–64.1 kg. Good WL was found in 75.7 of the cohort. 1-PWL response (4.7 %) was characterized by lesser WL but similar WR as compared to good WL and was associated with larger BMI and diabetes prior to surgery. 2-PWL response (19.6 %) was characterized by larger WR as compared to the other groups and was more common following SG. Lesser percentage of medical appointments kept was associated with 1-PWL and 2-PWL. Conclusion Our data show the high inter-individual variability of the WL response at mid-term after RYGB and SG and that poor WL after BS could be illustrated by two different patterns, characterized either by sustained limited WL (1-PWL), or pronounced weight regain (2-PWL).</description><subject>Adult</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastric Bypass</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMoWqs_wIssePGymkmz2exRi1ahoPiBx5BmJ3XLdlOTrdJ_b5ZVEcHL5DDPvJN5CDkCegaU5ucBQBRZSoGnkAFL8y0ygJzKlHImt8mAFoKmsmCjPbIfwoJSBoKxXbLHMs5AShiQ-3vdtuibkDibvGA1f22TqQshecCwck3A5NrVtfuomnky0aH1lUkuNysdCd2UyWON-I59B03rlpsDsmN1HfDw6x2S5-urp_FNOr2b3I4vpqnhnLVphqhLjhmVaEEYyW0htEFrLTciL2em5GWJYIQwOrPcznQhYs1h1t1s6GhITvvclXdvawytWlbBYF3rBt06KBAyHwkY0Q49-YMu3No38XcdJXIuC5pFCnrK-Hi_R6tWvlpqv1FAVadb9bpV1K063SqPM8dfyevZEsufiW-_EWA9EGKrmaP_tfrf1E9F7YtV</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>de Hollanda, Ana</creator><creator>Ruiz, Tania</creator><creator>Jiménez, Amanda</creator><creator>Flores, Lílliam</creator><creator>Lacy, Antonio</creator><creator>Vidal, Josep</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Patterns of Weight Loss Response Following Gastric Bypass and Sleeve Gastrectomy</title><author>de Hollanda, Ana ; Ruiz, Tania ; Jiménez, Amanda ; Flores, Lílliam ; Lacy, Antonio ; Vidal, Josep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5eead4e508ef16c84f96acefff4c67dbcd4dde1c66ca5f4fba964fb71b1169c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Gastric Bypass</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Hollanda, Ana</creatorcontrib><creatorcontrib>Ruiz, Tania</creatorcontrib><creatorcontrib>Jiménez, Amanda</creatorcontrib><creatorcontrib>Flores, Lílliam</creatorcontrib><creatorcontrib>Lacy, Antonio</creatorcontrib><creatorcontrib>Vidal, Josep</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health &amp; 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In this context, we aimed to assess patterns within the variability of weight loss (WL) after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Methods WL data from 658 subjects that underwent RYGB ( n  = 464) or SG ( n  = 194) as first BS were analyzed. Based on excess WL (EWL), subjects were categorized as good WL responders (EWL ≥ 50 % at nadir weight and throughout follow-up), primarily poor WL responders (1-PWL:EWL &lt; 50 % at nadir weight and thereafter), and secondarily poor WL responders (2-PWL:EWL ≥ 50 % at nadir weight, but &lt;50 % at last follow-up visit). Predictors associated with different WL outcomes were ascertained using regression analysis. Results Median follow-up was 55.7 months. Nadir EWL ranged 12.4–143.6 %; last follow-up visit EWL ranged −22.1–143.6 % and weight regain (WR) ranged 0–64.1 kg. Good WL was found in 75.7 of the cohort. 1-PWL response (4.7 %) was characterized by lesser WL but similar WR as compared to good WL and was associated with larger BMI and diabetes prior to surgery. 2-PWL response (19.6 %) was characterized by larger WR as compared to the other groups and was more common following SG. Lesser percentage of medical appointments kept was associated with 1-PWL and 2-PWL. Conclusion Our data show the high inter-individual variability of the WL response at mid-term after RYGB and SG and that poor WL after BS could be illustrated by two different patterns, characterized either by sustained limited WL (1-PWL), or pronounced weight regain (2-PWL).</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25421881</pmid><doi>10.1007/s11695-014-1512-7</doi><tpages>7</tpages></addata></record>
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source Springer Nature
subjects Adult
Female
Gastrectomy
Gastric Bypass
Gastrointestinal surgery
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Obesity
Obesity, Morbid - physiopathology
Obesity, Morbid - surgery
Original Contributions
Surgery
Treatment Outcome
Weight control
Weight Loss - physiology
title Patterns of Weight Loss Response Following Gastric Bypass and Sleeve Gastrectomy
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