Enhancement of the antibiofilm activity of amphotericin B by polyamine biosynthesis inhibitors

Highlights • Polyamine biosynthesis inhibitors can be used to enhance the activity of amphotericin B (AmB) against Candida albicans biofilms. • Polyamine biosynthesis inhibitors can also enhance the efficacy of caspofungin, miconazole and nystatin against C. albicans biofilms. • The combination of A...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2015-07, Vol.46 (1), p.45-52
Main Authors: Liao, ZeBin, ZhangGuan, XuanZi, Zhu, ZhenYu, Yao, XiangWen, Yang, Yu, Jiang, YuanYing, Cao, YingYing
Format: Article
Language:English
Subjects:
Amphotericin B
Amphotericin B - pharmacology
Anti-Infective Agents - pharmacology
Biofilm
Biofilms - drug effects
CaMCA1
Candida albicans
Candida albicans - drug effects
Candida albicans - physiology
Caspase
Drug Interactions
Eflornithine - pharmacology
Infectious Disease
Microbial Sensitivity Tests
Microbial Viability - drug effects
Polyamine biosynthesis inhibitor
Polyamines - pharmacology
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Summary:Highlights • Polyamine biosynthesis inhibitors can be used to enhance the activity of amphotericin B (AmB) against Candida albicans biofilms. • Polyamine biosynthesis inhibitors can also enhance the efficacy of caspofungin, miconazole and nystatin against C. albicans biofilms. • The combination of AmB and polyamine biosynthesis inhibitors increases reactive oxygen species levels in biofilm cells. • The caspase pathway mediated by CaMCA1 plays an essential role in enhancing the antibiofilm efficacy of AmB by polyamine biosynthesis inhibitors.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.02.021