Synthesis of 1,3,5-triazines via Cu(OAc)2-catalyzed aerobic oxidative coupling of alcohols and amidine hydrochlorides

Cu(OAc)2 was found to be an efficient catalyst for dehydrogenative synthesis of 1,3,5-triazine derivatives via oxidative coupling reaction of amidine hydrochlorides and alcohols in air. Both aromatic and aliphatic alcohols can be involved in the reaction and thirty-three products were obtained with...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2015-06, Vol.13 (24), p.6723-6727
Main Authors: You, Qing, Wang, Fei, Wu, Chaoting, Shi, Tianchao, Min, Dewen, Chen, Huajun, Zhang, Wu
Format: Article
Language:English
Subjects:
Alcohols - chemical synthesis
Alcohols - chemistry
Amidines - chemical synthesis
Amidines - chemistry
Catalysis
Chlorides - chemical synthesis
Chlorides - chemistry
Copper - chemistry
Oxidative Coupling
Triazines - chemical synthesis
Triazines - chemistry
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Summary:Cu(OAc)2 was found to be an efficient catalyst for dehydrogenative synthesis of 1,3,5-triazine derivatives via oxidative coupling reaction of amidine hydrochlorides and alcohols in air. Both aromatic and aliphatic alcohols can be involved in the reaction and thirty-three products were obtained with good to excellent yields. Moreover, the use of a ligand, strong base and organic oxidant is unnecessary.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00724k