Vitamin D serum levels are associated with handgrip strength but not with muscle mass or length of hospital stay after hip fracture

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-07, Vol.31 (7), p.931-934
• Main Authors: Gumieiro, David Nicoletti, M.D., Ph.D, Murino Rafacho, Bruna Paola, M.Sc, Buzati Pereira, Bruna Letícia, R.D., C.D.N, Cavallari, Karelin Alvisi, R.D., C.D.N, Tanni, Suzana Erico, M.D., Ph.D, Azevedo, Paula Schmidt, M.D., Ph.D, Polegato, Bertha Furlan, M.D., Ph.D, Mamede Zornoff, Leonardo Antonio, M.D., Ph.D, Dinhane, Daniel Innocenti, M.D, Innocenti Dinhane, Kandir Genésio, M.D, Cação Pereira, Gilberto José, M.D., Ph.D, de Paiva, Sergio Alberto Rupp, M.D., Ph.D, Minicucci, Marcos Ferreira, M.D., Ph.D
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Arm - anatomy & histology; Calcifediol - blood; Dynapenia; Female; Fractures; Gastroenterology and Hepatology; Hand Strength - physiology; Hip fracture; Hip Fractures - blood; Humans; Length of Stay - statistics & numerical data; Linear Models; Male; Mortality; Multivariate Analysis; Muscle, Skeletal - physiology; Osteoporosis; Regression analysis; Risk Factors; Sarcopenia; Studies; Vitamin D; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - epidemiology
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2014.12.022

Abstract Objectives The aim of this study was to evaluate the association between serum levels of 25(OH) vitamin D3 with midupper arm muscle circumference (MUAMC), handgrip strength and length of hospital stay (LOS) after hip fracture. Methods In total, 102 consecutive patients with hip fracture over the age of 65 were admitted to the orthopedic unit and prospectively evaluated. All of the patients were treated according to specific protocols depending on the type of fracture. Anthropometric measurements and handgrip strength were performed, and blood samples were taken for serum biochemistry and 25(OH) vitamin D3 analysis within the first 72 h of admission. All of the patients were followed during their hospital stay, and the length of stay was recorded. Results Of the patients, two were excluded because of pathologic fractures. In total, 100 patients with a mean age of 80 ± 7 y were included in the analysis. Among these patients, 73% were female, and 37% had vitamin D deficiency. The median LOS was 7 (5–11) d. Patients with vitamin D deficiency had lower handgrip strength in univariate analysis. In the multiple linear regression analysis with robust standard error, serum vitamin D levels adjusted by age and sex were associated with handgrip strength but not with MUAMC and LOS after hip fracture. Conclusions In conclusion, vitamin D serum levels were associated with handgrip strength but not with muscle mass or length of hospital stay after hip fracture.