The hepatoprotective role of Silymarin in isoniazid induced liver damage of rabbits

To evaluate the hepatoprotective role of Silymarin against isonicotinylhydrazine-induced hepatotoxicity in rabbit model. The experimental animal study was held at Jinnah Postgraduate Medical Centre, Karachi, from April to September 2013 and comprised rabbits weighing 1-1.5kgof either gender. The ani...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2015-06, Vol.65 (6), p.620-622
Main Authors: Jahan, Sarwat, Khan, Moosa, Imran, Sana, Sair, Mohammad
Format: Article
Language:English
Subjects:
Alanine Transaminase - drug effects
Alanine Transaminase - metabolism
Animals
Antitubercular Agents - toxicity
Bilirubin - metabolism
Chemical and Drug Induced Liver Injury - metabolism
Female
Isoniazid - toxicity
Liver
Liver - drug effects
Liver - metabolism
Liver diseases
Liver Function Tests
Male
Protective Agents - pharmacology
Rabbits
Random Allocation
Silymarin - pharmacology
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Summary:To evaluate the hepatoprotective role of Silymarin against isonicotinylhydrazine-induced hepatotoxicity in rabbit model. The experimental animal study was held at Jinnah Postgraduate Medical Centre, Karachi, from April to September 2013 and comprised rabbits weighing 1-1.5kgof either gender. The animals were divided randomly into equal groups: group I underwent liver function test without any drug; in group II effects of Silymarin (50mg/kg/day orally) was observed; in group III isoniazid (50mg/kg/dayorally) was administered; and in group IV combined effects of isoniazid and silymarin were observed. Liver function tests were performed at day0 and after the treatment at day19. SPSS 16 was used for statistical analysis. The 28 rabbits in the study were divided in four groups of 7(25%) each. No mortality was recorded in any group. In group III, bilirubin level was increased and alanine transaminase was decreased significantly (p
ISSN:0030-9982