Molecular Docking Studies of (1E,3E,5E)-1,6-Bis(substituted phenyl)hexa-1,3,5-triene and 1,4-Bis(substituted trans-styryl)benzene Analogs as Novel Tyrosinase Inhibitors

• Published in: Biological & pharmaceutical bulletin 2013/01/01, Vol.36(1), pp.55-65
• Main Authors: Ha, Young Mi, Lee, Hye Jin, Park, Daeui, Jeong, Hyoung Oh, Park, Ji Young, Park, Yun Jung, Lee, Kyung Jin, Lee, Ji Yeon, Moon, Hyung Ryong, Chung, Hae Young
• Format: Article
• Language: English
• Subjects: Benzene Derivatives - chemistry; docking simulation; Enzyme Inhibitors - chemistry; Molecular Docking Simulation; Monophenol Monooxygenase - antagonists & inhibitors; Monophenol Monooxygenase - chemistry; Polyenes - chemistry; Pyrones - chemistry; shared pharmacophore; Structure-Activity Relationship; tyrosinase inhibitory activity
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.b12-00605

We simulated the docking of the tertiary structure of mushroom tyrosinase with our compounds. From the structure-tyrosinase inhibitory activity relationship, it is notable that compounds 4, 8 and 11 showed similar or better activity rates than kojic acid which was used as a positive control. Compounds 17, 21, and 23 among benzene analogs that possess the same substituent showed significantly lower tyrosinase inhibitory effects. Therefore, we have confirmed that among the compounds showing better tyrosinase inhibitory effects than kojic acid, the compounds with triene analogs have better tyrosinase inhibitory effect than the compounds with benzene analogs. Docking simulation suggested the mechanism of compounds by several key residues which had possible hydrogen bonding interactions. The pharmacophore model underlined the features of active compounds, 4,4′-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)diphenol, 5,5′-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)bis(2-methoxy-phenol), and 5,5′-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)dibenzene-1,3-diol among triene derivatives which had several hydrogen bond groups on both terminal rings. The soundness of the docking results and the agreement with the pharmacophores suggest that it can be conveniently exploited to design inhibitors with an improved affinity for tyrosinase.