Endocrine evaluation after an intra-articular therapeutic dosage of dexamethasone in horses

This study investigated whether a single intra‐articular administration (IA) of dexamethasone (DEX) in horses at therapeutic dosage could exert a systemic effect by influencing the hypothalamic‐pituitary‐adrenal axis activity as a consequence of (limited) absorption and systemic distribution. The re...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 2013-12, Vol.36 (6), p.542-549
Main Authors: Capolongo, F., Gallina, G., Fidani, M., Baia, F., Montesissa, C.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Chromatography, Liquid
Dexamethasone - administration & dosage
Dexamethasone - pharmacology
Enzyme-Linked Immunosorbent Assay - veterinary
Horses - blood
Horses - urine
Hydrocortisone - analogs & derivatives
Hydrocortisone - blood
Hydrocortisone - urine
Injections, Intra-Articular
Male
Radioimmunoassay - veterinary
Tandem Mass Spectrometry
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Summary:This study investigated whether a single intra‐articular administration (IA) of dexamethasone (DEX) in horses at therapeutic dosage could exert a systemic effect by influencing the hypothalamic‐pituitary‐adrenal axis activity as a consequence of (limited) absorption and systemic distribution. The results indicated that DEX was detectable in urine collected 12–48 h after IA administration and that injection was accompanied by a reduced urine excretion of cortisol, 6β‐hydroxycortisol (6βOHF) and two other metabolites of cortisol lasting up to 48 h post‐DEX administration. The systemic effects in horses treated with DEX by IA route are similar to those that typically occur with short‐term treatment including the reduction in urinary cortisol concentration.
ISSN:0140-7783
1365-2885
DOI:10.1111/jvp.12046