Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coliinfections

Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac( alpha 2-3)Gal( beta 1-4)Glc beta -sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs with Enterotoxigenic Escherichia coli(ETEC) strain K99 (ECK99) is investigat...

Full description

Saved in:
Bibliographic Details
Published in:Nanoscale 2015-04, Vol.7 (18), p.8326-8331
Main Authors: Raval, Yash S, Stone, Roland, Fellows, Benjamin, Qi, Bin, Huang, Guohui, Mefford, OThompson, Tzeng, Tzuen-Rong J
Format: Article
Language:English
Subjects:
Escherichia
Nanoparticles
Nanostructure
Polyethylene oxides
Strain
Synthesis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac( alpha 2-3)Gal( beta 1-4)Glc beta -sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs with Enterotoxigenic Escherichia coli(ETEC) strain K99 (ECK99) is investigated using different microscopic techniques. Our results suggest that GM3-MNPs can effectively act as non-antibiotic anti-adhesion agents for treating ETEC infections.
ISSN:2040-3364
2040-3372
DOI:10.1039/c5nr00511f