Prevalence and Risk Factors for Adult Pulmonary Tuberculosis in a Metropolitan City of South India: e0124260

• Published in: PloS one 2015-04, Vol.10 (4)
• Main Authors: Dhanaraj, Baskaran, Papanna, Mohan Kumar, Adinarayanan, Srividya, Vedachalam, Chandrasekaran, Sundaram, Vijayaraj, Shanmugam, Shivakumar, Sekar, Gomathi, Menon, Pradeep Aravindan, Wares, Fraser, Swaminathan, Soumya
• Format: Article
• Language: English
• Subjects: Mycobacterium
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0124260

Background The present study measured the community prevalence and risk factors of adult pulmonary tuberculosis (PTB) in Chennai city, and also studied geographical distribution and the presence of different M. tuberculosis strains in the survey area. Methods A community-based cross sectional survey was carried out from July 2010 to October 2012 in Chennai city. Prevalence of bacteriologically positive PTB was estimated by direct standardization method. Univariate and multivariate analyses were carried out to identify significant risk factors. Drug susceptibility testing and spoligotyping was performed on isolated M. tuberculosis strains. Mapping of PTB cases was done using geographic positioning systems. Results Of 59,957 eligible people, 55,617 were screened by X-ray and /or TB symptoms and the prevalence of smear, culture, and bacteriologically positive PTB was estimated to be 228 (95% CI 189-265), 259 (95% CI 217-299) and 349 (95% CI 330-428) per 100,000 population, respectively. Prevalence of smear, culture, and bacteriologically positive PTB was highest amongst men aged 55-64 years. Multivariate analysis showed that occurrence of both culture and bacteriologically positive PTB disease was significantly associated with: age >35 years, past history of TB treatment, BMI