Improved anticancer delivery of paclitaxel by albumin surface modification of PLGA nanoparticles

Nanoparticles (NP) play an important role in anticancer delivery systems. Surface modified NPs with hydrophilic polymers such as human serum albumin (HSA) have long half-life in the blood circulation system. The method of modified nanoprecipitation was utilized for encapsulation of paclitaxel (PTX)...

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Published in:Daru 2015-04, Vol.23 (4), p.1-1
Main Authors: Esfandyari-Manesh, Mehdi, Mostafavi, Seyed Hossein, Majidi, Reza Faridi, Koopaei, Mona Noori, Ravari, Nazanin Shabani, Amini, Mohsen, Darvishi, Behrad, Ostad, Seyed Nasser, Atyabi, Fatemeh, Dinarvand, Rassoul
Format: Article
Language:English
Subjects:
Cancer
Cytotoxicity
Efficiency
Nanoparticles
Polyethylene glycol
Polyvinyl alcohol
Studies
Surfactants
Tumors
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Summary:Nanoparticles (NP) play an important role in anticancer delivery systems. Surface modified NPs with hydrophilic polymers such as human serum albumin (HSA) have long half-life in the blood circulation system. The method of modified nanoprecipitation was utilized for encapsulation of paclitaxel (PTX) in poly (lactic-co-glycolic acid). Para-maleimide benzoic hydrazide was conjugated to PLGA for the surface modifications of PLGA NPs, and then HSA was attached on the surface of prepared NPs by maleimide attachment to thiol groups of albumin. The particle size of NPs ranged from 170 HM to 190 nm and increased about 20 nm-30 nm after HSA conjugation. The zeta potential was about -6 mV and it decreased further after HSA conjugation. The HSA conjugation in prepared NPs was proved by Fourier transform infrared spectroscopy, faster degradation of HSA in Differential scanning calorimetry characterization, and other evidences such as the increasing in size and the decreasing in zeta potential. The PTX released in a biphasic mode for all colloidal suspensions.
ISSN:1560-8115
2008-2231