Steroidal Alkaloids from Veratrum maackii Regel with Genotoxicity on Brain-Cell DNA in Mice

Two new steroidal alkaloids, 23‐methoxycyclopamine 3‐O‐β‐D‐glucopyranoside (1) and isoecliptalbine (2), were isolated from the root and rhizoma of Veratrum maackii Regel, together with five known compounds, i.e., verussurine (3), verabenzoamine (4), verazine (5), isoverazine (6), and verazinine (7)....

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Bibliographic Details
Published in:Helvetica chimica acta 2015-04, Vol.98 (4), p.539-545
Main Authors: Cong, Yue, Zhu, Hua-Lan, Zhang, Qing-Chun, Li, Lin, Li, Hai-Yan, Wang, Xian-You, Guo, Jing-Gong
Format: Article
Language:English
Subjects:
23-methoxy
Alkaloids
Cyclopamine 3-O-β-D-glucopyranoside
Cyclopamine 3‐O‐β‐D‐glucopyranoside, 23‐methoxy
Deoxyribonucleic acid
DNA
Genotoxicity
Isoecliptalbine
Medical research
Veratrum
Veratrum maackii
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Summary:Two new steroidal alkaloids, 23‐methoxycyclopamine 3‐O‐β‐D‐glucopyranoside (1) and isoecliptalbine (2), were isolated from the root and rhizoma of Veratrum maackii Regel, together with five known compounds, i.e., verussurine (3), verabenzoamine (4), verazine (5), isoverazine (6), and verazinine (7). Their structures were established by extensive analysis of spectroscopic data, as well as by comparison with literature data. Compounds 1–7 could cause DNA damage in the cerebellum and cerebral cortex of mice in a dose‐dependent manner by using single‐cell gel electrophoresis (comet assay).
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201400238