Antimicrobial and Cytotoxic Activity of the Methanol Extract of Paederia foetida Linn. (Rubiaceae)

The antibacterial activities of n-hexane, chloroform, ethyl acetate fractions of methanolic extracts of the whole plants Paederia foetida (family Rubiaceae) were screened against various pathogenic bacteria such as Bacillus cereus, Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus, Sarci...

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Bibliographic Details
Published in:Journal of applied pharmaceutical science 2012-01, Vol.2 (1), p.77-80
Main Authors: Morshed, Helal, Islam, MdSiddiqul, Parvin, Salma, Ahmed, Maizbha Uddin, Islam, Mohammad Safiqul, Mostofa, A G M, Sayeed, Muhammad Shahdaat Bin
Format: Article
Language:English
Subjects:
Aspergillus niger
Bacillus cereus
Bacillus megaterium
Bacillus subtilis
Candida albicans
Decapoda
Escherichia coli
Paederia foetida
Pseudomonas aeruginosa
Rubiaceae
Salmonella paratyphi
Salmonella typhi
Sarcina
Shigella boydii
Shigella dysenteriae
Staphylococcus aureus
Vibrio
Vibrio mimicus
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Summary:The antibacterial activities of n-hexane, chloroform, ethyl acetate fractions of methanolic extracts of the whole plants Paederia foetida (family Rubiaceae) were screened against various pathogenic bacteria such as Bacillus cereus, Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus, Sarcina lutea, Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphi , Salmonella typhi, Shigella boydii, Shigella dysenteriae, Vibrio mimicus, Vibrio parahemolyticus, Candida albicans, Aspergillus niger, Sacharomyces cerevacae by a~disc diffusion methoda[tm]. The methanol extract of the whole plants possesses no antimicrobial activity but the ethyl acetate, chloroform and n-hexane fractions exhibited moderate to less activity against some organisms tested compared with the standard antibiotic Kanamycin. Brine shrimp lethality bio-assay was done using brine shrimp Nauplii and dimethyl sulfoxide as a solvent for the methanol plant extracts of Paederia foetida. The LC50 value of methanol extract of the plant indicated that the cytotoxicity was very significant.
ISSN:2231-3354