Chromatographic Determination of Methyl Glyoxal in Blood Plasma as the Test for Glycotoxicity and Accumulation of Glycation End-Products

We developed a method of measuring methyl glyoxal concentration in blood serum using HPLC with UV detection. Methyl glyoxal concentration was determined in healthy subjects. The method was developed for indirect but reliable measurement of the levels of glycation end-products in patients with diabet...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-05, Vol.153 (1), p.114-117
Main Authors: Shiryaeva, Yu. K., Krylin, V. V., Titov, V. N.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological products
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chromatography, High Pressure Liquid
Female
Glucose metabolism
Glycation End Products, Advanced - blood
Glycosylation
Glyoxal - blood
Humans
Internal Medicine
Laboratory Medicine
Liquid chromatography
Male
Methods
Middle Aged
Pathology
Physiological aspects
Plasma - chemistry
Young Adult
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Description
Summary:We developed a method of measuring methyl glyoxal concentration in blood serum using HPLC with UV detection. Methyl glyoxal concentration was determined in healthy subjects. The method was developed for indirect but reliable measurement of the levels of glycation end-products in patients with diabetes, hyperlipidemia, and cardiovascular pathologies.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1656-1