Protein synthesis in artificial cells: using compartmentalisation for spatial organisation in vesicle bioreactors

Whereas spatial organisation of function is ubiquitous in biology, it has been lacking in artificial cells. We rectify this by using multi-compartment vesicles as chassis for artificial cells, allowing distinct biological processes to be isolated in space. This is demonstrated by in vitro synthesis...

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Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2015-06, Vol.17 (24), p.15534-15537
Main Authors: Elani, Yuval, Law, Robert V, Ces, Oscar
Format: Article
Language:English
Subjects:
Artificial Cells - chemistry
Artificial Cells - metabolism
Bioreactors
Cell Compartmentation
Protein Biosynthesis
Proteins - chemistry
Proteins - metabolism
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Summary:Whereas spatial organisation of function is ubiquitous in biology, it has been lacking in artificial cells. We rectify this by using multi-compartment vesicles as chassis for artificial cells, allowing distinct biological processes to be isolated in space. This is demonstrated by in vitro synthesis of two proteins in predefined vesicle regions.
ISSN:1463-9076
1463-9084
DOI:10.1039/c4cp05933f