Did Colchicine Prove Useful in the Prevention of Postoperative Atrial Fibrillation?

Colchicine was initiated 48 to 72 hours preoperatively in the COPPS-2 study (in contrast to the COPPS study in which it was initiated postoperatively), and this was postulated as the cause related to its poor tolerance in patients undergoing major cardiac surgery who may be more vulnerable to its as...

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Bibliographic Details
Published in:The American journal of cardiology 2015-07, Vol.116 (1), p.165-165
Main Authors: Chhabra, Lovely, MD, Spodick, David H., MD
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - surgery
Cardiac arrhythmia
Cardiology
Cardiovascular
Cardiovascular disease
Colchicine - administration & dosage
Compliance
Coronary Artery Bypass - adverse effects
Coronary vessels
Creatine Kinase, MB Form - blood
Disease prevention
Female
Heart attacks
Heart surgery
Humans
Male
Patients
Perioperative Care - methods
Postoperative Complications - prevention & control
Troponin T - blood
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Description
Summary:Colchicine was initiated 48 to 72 hours preoperatively in the COPPS-2 study (in contrast to the COPPS study in which it was initiated postoperatively), and this was postulated as the cause related to its poor tolerance in patients undergoing major cardiac surgery who may be more vulnerable to its associated side effects. [...]recently, it was believed that postoperative initiation of colchicine (probably on the second or third postoperative day after a major/cardiac surgery) would be rather better than preoperative initiation to improve its compliance and gain its beneficial effects.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2015.04.008