Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment

Background The following review is a compilation of the recent advances and knowledge on the behaviour of the most frequently used compounds to treat inflammatory bowel disease in an organism. Results It considers clinical aspects of each entity and the pharmacokinetic/pharmacodynamic relationship s...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2015-07, Vol.71 (7), p.773-799
Main Authors: Quetglas, E. G., Armuzzi, A., Wigge, S., Fiorino, G., Barnscheid, L., Froelich, M., Danese, Silvio
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - adverse effects
Anti-Inflammatory Agents - pharmacokinetics
Anti-Inflammatory Agents - therapeutic use
Biomedical and Life Sciences
Biomedicine
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - immunology
Crohn Disease - diagnosis
Crohn Disease - drug therapy
Crohn Disease - immunology
Crohn's disease
Drug Monitoring
Gastrointestinal Agents - adverse effects
Gastrointestinal Agents - pharmacokinetics
Gastrointestinal Agents - therapeutic use
Humans
Inflammatory bowel disease
Kinetics
Pharmacogenetics
Pharmacology
Pharmacology/Toxicology
Remission Induction
Review Article
Treatment Outcome
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Summary:Background The following review is a compilation of the recent advances and knowledge on the behaviour of the most frequently used compounds to treat inflammatory bowel disease in an organism. Results It considers clinical aspects of each entity and the pharmacokinetic/pharmacodynamic relationship supported by the use of plasma monitoring, tissue concentrations, and certain aspects derived from pharmacogenetics.
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-015-1862-7