Primary Enteropathy-Associated T-Cell Lymphoma Type 2: An Emerging Entity?

Intestinal T-cell lymphoma is a rare hematological malignancy that can present as primary intestinal lymphoma or as a manifestation of systemic disease. Primary involvement accounts for approximately 0.1% to 0.5% of all colorectal neoplasms. It is an aggressive disease with a poor prognosis and low...

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Bibliographic Details
Published in:Cancer control 2015-04, Vol.22 (2), p.242-247
Main Authors: Grigg-Gutierrez, Nicole M, Estremera-Marcial, Rodolfo, Caceres, William W, Toro, Doris H
Format: Article
Language:English
Subjects:
Aged
Care and treatment
Case studies
Colonoscopy
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - pathology
Diagnosis
Enteropathy-Associated T-Cell Lymphoma - diagnosis
Enteropathy-Associated T-Cell Lymphoma - pathology
Humans
Immunohistochemistry
Lymphomas
Male
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Summary:Intestinal T-cell lymphoma is a rare hematological malignancy that can present as primary intestinal lymphoma or as a manifestation of systemic disease. Primary involvement accounts for approximately 0.1% to 0.5% of all colorectal neoplasms. It is an aggressive disease with a poor prognosis and low survival rate. Inflammatory bowel disease, celiac disease, immunosuppression, and infectious etiologies, such as Epstein-Barr and human T-lymphotropic viruses, have been reported as risk factors, but no direct causal link has been established. Herein, we examine the case of a Hispanic man 69 years of age diagnosed with positive CD3, CD7, CD8, CD43, and Bcl-2 diffuse primary colorectal T-cell lymphoma. The patient did not exhibit a concomitant autoimmune or genetic disease. Because of the patient's history of polyps, surveillance colonoscopy was performed and the diagnosis was confirmed.
ISSN:1073-2748
1526-2359
1073-2748
DOI:10.1177/107327481502200218