Bioactivity and mechanism of action of Lophozozymus pictor toxin

The bioactivity of Lophozozymus pictor toxin (LPTX) and the possible mechanism of action of the purified toxin are described. LPTX is found to possess palytoxin-like bioactivities. Besides exhibiting cytotoxic and haemolytic properties, LPTX causes the release of K + from erythrocytes and inhibits 2...

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Bibliographic Details
Published in:Toxicon (Oxford) 1995-07, Vol.33 (7), p.901-908
Main Authors: Lau, C.O., Tan, C.H., Li, Q.T., Ng, F.H., Yuen, R., Khoo, H.E.
Format: Article
Language:English
Subjects:
Animal poisons toxicology. Antivenoms
Animals
Biological and medical sciences
Brachyura - chemistry
HeLa Cells
Humans
Lophozozymus pictor
Marine
Marine Toxins - antagonists & inhibitors
Marine Toxins - chemistry
Marine Toxins - pharmacology
Medical sciences
Mitochondria, Liver - drug effects
Ouabain - pharmacology
Rats
Rats, Wistar
Sodium-Potassium-Exchanging ATPase - drug effects
Sphingomyelins - pharmacology
Toxicology
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Summary:The bioactivity of Lophozozymus pictor toxin (LPTX) and the possible mechanism of action of the purified toxin are described. LPTX is found to possess palytoxin-like bioactivities. Besides exhibiting cytotoxic and haemolytic properties, LPTX causes the release of K + from erythrocytes and inhibits 2-[ 14C]deoxy-D-glucose uptake into HeLa cells. Although LPTX acts on HeLa cell and erythrocyte membranes, it does not interact with mitochondrial or liposomal membranes containing different phospholipid compositions. Ouabain, but not sphingomyelin, is able to prevent the toxic effects of LPTX. This antagonistic effect of ouabain on LPTX suggests that the toxin might mediate its toxic effects via the membrane Na + K + - ATPase but not through interaction with membrane lipids.
ISSN:0041-0101
1879-3150
DOI:10.1016/0041-0101(95)00028-K