The effect of cholinoceptor agonists and neurotoxins on the release of vasopressin in the rat in relation to the subunit composition of the cholinoceptor

The effects of cholinoceptor agonists and neurotoxins on the release of vasopressin and oxytocin have been investigated in water-loaded rats under ethanol anaesthesia. Release of vasopressin was monitored by antidiuretic responses accompanied by increased urinary excretion of vasopressin. The rate o...

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Bibliographic Details
Published in:Neuroscience letters 1995-03, Vol.188 (2), p.77-80
Main Authors: Bisset, G.W., Fairhall, K.M.
Format: Article
Language:English
Subjects:
a-Bungarotoxin
Alkaloids - antagonists & inhibitors
Alkaloids - pharmacology
Animals
Azocines
Biological and medical sciences
Cholinergic Agents - pharmacology
Cytisine
Diuresis - drug effects
Fundamental and applied biological sciences. Psychology
Hormones and neuropeptides. Regulation
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Neosurugatoxin
Neuronal bungarotoxin
Neurotoxins - pharmacology
Nicotine
Nicotine - pharmacology
Oxytocin
Oxytocin - urine
Quinolizines
Rats
Vasopressin
Vasopressins - metabolism
Vasopressins - urine
Vertebrates: endocrinology
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Summary:The effects of cholinoceptor agonists and neurotoxins on the release of vasopressin and oxytocin have been investigated in water-loaded rats under ethanol anaesthesia. Release of vasopressin was monitored by antidiuretic responses accompanied by increased urinary excretion of vasopressin. The rate of excretion of oxytocin-like radioimmunoreactivity was measured as an indicator of oxytocin release. Both nicotine and cytisine caused a preferential release of vasopressin. The release by nicotine was not inhibited by α- or neuronal-bungarotoxin. Neosurugatoxin blocked the release by cytisine. Comparison with the effects of these agents on combinations of α and β subunits expressed in oocytes suggests that the central cholinoceptors mediating release of vasopressin are similar to those at autonomic ganglia and may contain a β4 subunit.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(95)11399-H