Transformation of myelomonocytic cells by the avian myeloblastosis virus is determined by the v-myb oncogene, not by the unique long terminal repeats of the virus

The avian myeloblastosis virus (AMV) induces acute monoblastic leukemia in chickens and transforms only myelomonocytic cells in vitro. The long terminal repeat (LTR) regulatory region of AMV is unique among the known classes of avian retrovirus LTRs. We demonstrate that the substitution of the AMV L...

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Bibliographic Details
Published in:Journal of Virology 1994-04, Vol.68 (4), p.2752-2755
Main Authors: Engelke, U, Lipsick, J.S
Format: Article
Language:English
Subjects:
ADN
Animals
avian myeloblastosis virus
Avian Myeloblastosis Virus - genetics
Base Sequence
Biological and medical sciences
CARCINOGENOS
Cell Transformation, Viral - genetics
CELLULE SANGUINE
CELULAS SANGUINEAS
Chick Embryo
Fundamental and applied biological sciences. Psychology
GENE
GENES
GENOMAS
GENOME
Genome, Viral
Helper Viruses - genetics
Hematopoietic Stem Cells - microbiology
Microbiology
Molecular Sequence Data
NEOPLASMAS
NEOPLASME
Oncogenes
ONCOVIRUS AVIAIRE
ONCOVIRUS AVIAR
POLLO
POULET
Proviruses - genetics
Repetitive Sequences, Nucleic Acid
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
SUBSTANCE CANCERIGENE
Virology
Citations: Items that cite this one
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Description
Summary:The avian myeloblastosis virus (AMV) induces acute monoblastic leukemia in chickens and transforms only myelomonocytic cells in vitro. The long terminal repeat (LTR) regulatory region of AMV is unique among the known classes of avian retrovirus LTRs. We demonstrate that the substitution of the AMV LTRs by Rous sarcoma virus LTRs did not alter the cell type specificity or the transforming ability of the virus
ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.68.4.2752-2755.1994