Effects of chronic alcohol intake on the vasopressin content in the hypothalamic paraventricular and supraoptic nuclei of the mouse. An immunohistochemical and morphometric study

The present study analyses the response of the paraventricular (PVN) and supraoptic (SPO) nuclei of the hypothalamus of the male mouse to chronic alcohol intake by immunohistochemical and morphometric methods. We relate the intensity of the reaction to A-V with the vasopressin content of the nucleus...

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Bibliographic Details
Published in:Drug and alcohol dependence 1995-04, Vol.38 (1), p.19-24
Main Authors: Carmona-Calero, Emilia, del Mar Pérez-Delgado, María, Bañuelos-Pineda, Jacinto, Marrero-Gordillo, Norberto, Ferres-Torres, Romualdo, Castañeyra-Perdomo, Agustín
Format: Article
Language:English
Subjects:
Alcohol
Alcoholism - pathology
Alcoholism and acute alcohol poisoning
Animals
Arginine Vasopressin - metabolism
Biological and medical sciences
Hypothalamus
Image Processing, Computer-Assisted
Immunoenzyme Techniques
Male
Medical sciences
Mice
Paraventricular
Paraventricular Hypothalamic Nucleus - pathology
Supraoptic
Supraoptic Nucleus - pathology
Toxicology
Vasopressin
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Summary:The present study analyses the response of the paraventricular (PVN) and supraoptic (SPO) nuclei of the hypothalamus of the male mouse to chronic alcohol intake by immunohistochemical and morphometric methods. We relate the intensity of the reaction to A-V with the vasopressin content of the nucleus, as all the slides, from the control and experimental groups, were processed at the same time and with the same solutions of the antibodies. We suggest that the accumulation of vasopressin, observed in the alcohol-treated animals, of both hypothalamic nuclei could be related to an inhibition of vasopressin release and/or transport from the SPO and PVN to the neurohypophysis and to an increase in vasopressin synthesis in the SPO as this nucleus shows an increase in its nuclear sizes, an index of the function of the neurons.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(95)01095-G