Effects of ferulic acid on antioxidant activity in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and their combination

The present study aimed at exploring different roles of the same compound in different environment, using preparative HPLC, and the significance to investigating bio-active constituents in traditional Chinese medicine (TCM) on the basis of holism. In this study, the depletion of target component fer...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2015-06, Vol.13 (6), p.401-408
Main Authors: WANG, Lin-Yan, TANG, Yu-Ping, LIU, Xin, ZHU, Min, TAO, Wei-Wei, LI, Wei-Xia, DUAN, Jin-Ao
Format: Article
Language:English
Subjects:
Angelica sinensis
Angelica sinensis - chemistry
Antioxidant activity
Antioxidants - analysis
Chromatography, High Pressure Liquid
Coumaric Acids - analysis
Drugs, Chinese Herbal - analysis
Ferulic acid
Herb pair
HPLC
Ligusticum chuanxiong
Rhizome - chemistry
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Summary:The present study aimed at exploring different roles of the same compound in different environment, using preparative HPLC, and the significance to investigating bio-active constituents in traditional Chinese medicine (TCM) on the basis of holism. In this study, the depletion of target component ferulic acid (FA) by using preparative HPLC followed by antioxidant activity testing was applied to investigate the roles of FA in Angelicae Sinensis Radix (DG), Chuanxiong Rhizoma (CX) and their combination (GX). The antioxidant activity was performed by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity testing. FA was successfully and exclusively depleted from DG, CX, and GX, respectively. By comparing the effects of the samples, it was found that FA was one of the main antioxidant constituents in DG, CX and GX, and the roles of FA were DG > CX > GX. Furthermore, the effects of FA varied at different doses in these herbs. This study provided a reliable and effective approach to clarifying the contribution of same compound in different TCMs to their bio-activities. The role of a constituent in different TCMs might be different, and a component with the same content might have different effects in different chemical environments. Furthermore, this study also suggested the potential utilization of preparative HPLC in the characterization of the roles of multi-ingredients in TCM. [Display omitted]
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(15)30032-7