Effect of MTHFR, TGFβ1, and TNFB polymorphisms on osteoporosis in rheumatoid arthritis patients

Diseases of the immune and the skeletal systems should be studied together for the deep interaction between them. Many studies consider osteoporosis (OP) as a risk factor for the prediction of disease progression in rheumatoid arthritis (RA). The aim of this research is to study the effect of four s...

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Bibliographic Details
Published in:Gene 2015-09, Vol.568 (2), p.124-128
Main Authors: Saad, Mohamed N., Mabrouk, Mai S., Eldeib, Ayman M., Shaker, Olfat G.
Format: Article
Language:English
Subjects:
Adult
Arthritis, Rheumatoid - genetics
Case-Control Studies
Egyptian population
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Lymphotoxin-alpha - genetics
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
MTHFR
Osteoporosis
Osteoporosis - genetics
Polymorphism, Single Nucleotide
Rheumatoid arthritis
Sequence Analysis, DNA
Single nucleotide polymorphism
TGFβ1
TNFB
Transforming Growth Factor beta1 - genetics
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Summary:Diseases of the immune and the skeletal systems should be studied together for the deep interaction between them. Many studies consider osteoporosis (OP) as a risk factor for the prediction of disease progression in rheumatoid arthritis (RA). The aim of this research is to study the effect of four single nucleotide polymorphisms (SNPs) on RA patients with and without OP. The examined SNPs (MTHFR (C677T, and A1298C), TGFβ1 (T869C), and TNFB (A252G)) were tested by genotyping 17 RA patients with OP and 72 RA patients without OP. Associations were tested using four models (multiplicative, dominant, recessive, and co-dominant). The studied SNPs were not significantly associated with the risk of OP in RA. MTHFR, TGFβ1, and TNFB polymorphisms don't appear to be clinically useful genetic markers for predicting RA severity in Egyptian women population. [Display omitted] •MTHFR C677T was not associated with osteoporosis in rheumatoid arthritis patients.•MTHFR A1298C was not associated with osteoporosis in rheumatoid arthritis patients.•TGFβ1 T869C was not associated with osteoporosis in rheumatoid arthritis patients.•TNFB A252G was not associated with osteoporosis in rheumatoid arthritis patients.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2015.05.037