Effect of MTHFR, TGFβ1, and TNFB polymorphisms on osteoporosis in rheumatoid arthritis patients

• Published in: Gene 2015-09, Vol.568 (2), p.124-128
• Main Authors: Saad, Mohamed N., Mabrouk, Mai S., Eldeib, Ayman M., Shaker, Olfat G.
• Format: Article
• Language: English
• Subjects: Adult; Arthritis, Rheumatoid - genetics; Case-Control Studies; Egyptian population; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Lymphotoxin-alpha - genetics; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; MTHFR; Osteoporosis; Osteoporosis - genetics; Polymorphism, Single Nucleotide; Rheumatoid arthritis; Sequence Analysis, DNA; Single nucleotide polymorphism; TGFβ1; TNFB; Transforming Growth Factor beta1 - genetics
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2015.05.037

Diseases of the immune and the skeletal systems should be studied together for the deep interaction between them. Many studies consider osteoporosis (OP) as a risk factor for the prediction of disease progression in rheumatoid arthritis (RA). The aim of this research is to study the effect of four single nucleotide polymorphisms (SNPs) on RA patients with and without OP. The examined SNPs (MTHFR (C677T, and A1298C), TGFβ1 (T869C), and TNFB (A252G)) were tested by genotyping 17 RA patients with OP and 72 RA patients without OP. Associations were tested using four models (multiplicative, dominant, recessive, and co-dominant). The studied SNPs were not significantly associated with the risk of OP in RA. MTHFR, TGFβ1, and TNFB polymorphisms don't appear to be clinically useful genetic markers for predicting RA severity in Egyptian women population. [Display omitted] •MTHFR C677T was not associated with osteoporosis in rheumatoid arthritis patients.•MTHFR A1298C was not associated with osteoporosis in rheumatoid arthritis patients.•TGFβ1 T869C was not associated with osteoporosis in rheumatoid arthritis patients.•TNFB A252G was not associated with osteoporosis in rheumatoid arthritis patients.