Relationship of apelin, procalcitonin, and fetuin-A concentrations with carotid intima-media thickness in acromegaly

Background Acromegaly is characterized by excess growth hormone and insulin-like growth factor-1 concentrations. There is conflicting evidence as to whether acromegaly is associated with an increased risk of atherosclerosis. Apelin is an adipose tissue-derived peptide that may be associated with hyp...

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Bibliographic Details
Published in:Annals of clinical biochemistry 2015-07, Vol.52 (4), p.456-461
Main Authors: Topsakal, S, Akin, F, Turgut, S, Yaylali, GF, Herek, D, Ayada, C
Format: Article
Language:English
Subjects:
Acromegaly - blood
Acromegaly - diagnosis
Adult
alpha-2-HS-Glycoprotein - analysis
Apelin
Calcitonin - blood
Calcitonin Gene-Related Peptide
Carotid Intima-Media Thickness
Case-Control Studies
Female
Humans
Intercellular Signaling Peptides and Proteins - blood
Male
Middle Aged
Protein Precursors - blood
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Summary:Background Acromegaly is characterized by excess growth hormone and insulin-like growth factor-1 concentrations. There is conflicting evidence as to whether acromegaly is associated with an increased risk of atherosclerosis. Apelin is an adipose tissue-derived peptide that may be associated with hyperinsulinemia. Fetuin-A is a hepatocyte produced plasma glycoprotein that has an important role as a calcification inhibitor. The aim of this study was to examine apelin, fetuin-A, and procalcitonin concentrations and to assess their relationship with carotid intima medial thickness (cIMT) in subjects with acromegaly. Methods Apelin, fetuin-A, and procalcitonin serum concentrations were measured in 37 (20 inactive and 17 active) subjects with acromegaly and 30 control subjects, along with carotid intima medial thickness. Results The concentrations of apelin, fetuin-A, and procalcitonin were increased in subjects with acromegaly. There were significant correlations between apelin, fetuin-A, and procalcitonin in subjects with acromegaly. Carotid intima medial thickness values were similar between control subjects and subjects with acromegaly. Conclusions Carotid intima medial thickness was not increased in subjects with acromegaly. It is possible that the increased apelin and fetuin-A concentrations observed play a protective role against the development of atherosclerosis in subjects with acromegaly.
ISSN:0004-5632
1758-1001
DOI:10.1177/0004563214562431