Effect of 2-amino-4-phosphonobutyrate on ERG OFF-response after glycinergic and GABAergic blockade

Superfusion with 200 μM 2-amino-4-phosphonobutyrate (APB) of dark and chromatically adapted frog eyecups caused marked potentiation of the ERG OFF-response ( d-wave). Blockade of the glycinergic synapses by strychnine did not change this effect at all. Blockade of the GABAergic synapses by picrotoxi...

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Bibliographic Details
Published in:Vision research (Oxford) 1995-07, Vol.35 (14), p.1945-1949
Main Authors: Popova, Elka, Kupenova, Petja, Vitanova, Lilia, Mitova, Liljana
Format: Article
Language:English
Subjects:
Adaptation, Ocular - drug effects
Aminobutyrates - pharmacology
Animals
APB
Biological and medical sciences
Color
Dark Adaptation - drug effects
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
GABA
gamma-Aminobutyric Acid - metabolism
Glycine
Glycine - metabolism
In Vitro Techniques
Picrotoxin - pharmacology
Rana ridibunda
Retina
Retina - drug effects
Strychnine - pharmacology
Synapses - drug effects
Synaptic Transmission - drug effects
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Superfusion with 200 μM 2-amino-4-phosphonobutyrate (APB) of dark and chromatically adapted frog eyecups caused marked potentiation of the ERG OFF-response ( d-wave). Blockade of the glycinergic synapses by strychnine did not change this effect at all. Blockade of the GABAergic synapses by picrotoxin slightly diminished the effect of APB in chromatically-adapted eyes with isolated cones' activity, and did not change it in dark-adapted eyes. The results indicate that the action of APB on ERG OFF-response does not depend significantly on GABAergic and glycinergic neurotransmission in frog retina.
ISSN:0042-6989
1878-5646
DOI:10.1016/0042-6989(94)00310-I