Serum biomarkers predictive of pre-eclampsia

We sought serum biomarkers predictive of pre-eclampsia (PE). : Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach. Many statistically significant serum PE biomarker...

Full description

Saved in:
Bibliographic Details
Published in:Biomarkers in medicine 2015-06, Vol.9 (6), p.563-575
Main Authors: Anand, Swati, Bench Alvarez, Tanielle Mei, Johnson, W Evan, Esplin, M Sean, Merrell, Karen, Porter, T Flint, Graves, Steven W
Format: Article
Language:English
Subjects:
Adult
Biological markers
Biomarkers
Biomarkers - blood
Blood pressure
Blood Proteins - metabolism
Diagnosis
early diagnosis
Female
Gynecology
Humans
Hypertension
Identification and classification
Lipids
Mass spectrometry
Methods
Molecular weight
Obstetrics
pre-eclampsia
Pre-Eclampsia - blood
Preeclampsia
Pregnancy
Proteins
Proteomics - methods
Scientific imaging
Sensitivity and Specificity
serum proteomics
Studies
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We sought serum biomarkers predictive of pre-eclampsia (PE). : Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach. Many statistically significant serum PE biomarker candidates (n > 60) were found comparing cases and controls. In addition, logistic regression analysis modeled biomarker data resulted in 14 different multimarker combinations having high detection sensitivity and specificity (AUC >0.9). Developed panels of serum biomarkers appeared effective in identifying pregnant women at 12-14 weeks gestation at risk of PE later in their pregnancy.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm.15.21