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Serum biomarkers predictive of pre-eclampsia
We sought serum biomarkers predictive of pre-eclampsia (PE). : Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach. Many statistically significant serum PE biomarker...
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| Published in: | Biomarkers in medicine 2015-06, Vol.9 (6), p.563-575 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c496t-7ad308b359d0cba7c21e63f6d78cddc394617c48cf4b9c91a7a7ace35378ff713 |
| container_end_page | 575 |
| container_issue | 6 |
| container_start_page | 563 |
| container_title | Biomarkers in medicine |
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| creator | Anand, Swati Bench Alvarez, Tanielle Mei Johnson, W Evan Esplin, M Sean Merrell, Karen Porter, T Flint Graves, Steven W |
| description | We sought serum biomarkers predictive of pre-eclampsia (PE).
: Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach.
Many statistically significant serum PE biomarker candidates (n > 60) were found comparing cases and controls. In addition, logistic regression analysis modeled biomarker data resulted in 14 different multimarker combinations having high detection sensitivity and specificity (AUC >0.9).
Developed panels of serum biomarkers appeared effective in identifying pregnant women at 12-14 weeks gestation at risk of PE later in their pregnancy. |
| doi_str_mv | 10.2217/bmm.15.21 |
| format | article |
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: Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach.
Many statistically significant serum PE biomarker candidates (n > 60) were found comparing cases and controls. In addition, logistic regression analysis modeled biomarker data resulted in 14 different multimarker combinations having high detection sensitivity and specificity (AUC >0.9).
Developed panels of serum biomarkers appeared effective in identifying pregnant women at 12-14 weeks gestation at risk of PE later in their pregnancy.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm.15.21</identifier><identifier>PMID: 26079961</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Adult ; Biological markers ; Biomarkers ; Biomarkers - blood ; Blood pressure ; Blood Proteins - metabolism ; Diagnosis ; early diagnosis ; Female ; Gynecology ; Humans ; Hypertension ; Identification and classification ; Lipids ; Mass spectrometry ; Methods ; Molecular weight ; Obstetrics ; pre-eclampsia ; Pre-Eclampsia - blood ; Preeclampsia ; Pregnancy ; Proteins ; Proteomics - methods ; Scientific imaging ; Sensitivity and Specificity ; serum proteomics ; Studies ; Womens health</subject><ispartof>Biomarkers in medicine, 2015-06, Vol.9 (6), p.563-575</ispartof><rights>Future Medicine Ltd</rights><rights>COPYRIGHT 2015 Future Medicine Ltd.</rights><rights>2015 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-7ad308b359d0cba7c21e63f6d78cddc394617c48cf4b9c91a7a7ace35378ff713</citedby><cites>FETCH-LOGICAL-c496t-7ad308b359d0cba7c21e63f6d78cddc394617c48cf4b9c91a7a7ace35378ff713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26079961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anand, Swati</creatorcontrib><creatorcontrib>Bench Alvarez, Tanielle Mei</creatorcontrib><creatorcontrib>Johnson, W Evan</creatorcontrib><creatorcontrib>Esplin, M Sean</creatorcontrib><creatorcontrib>Merrell, Karen</creatorcontrib><creatorcontrib>Porter, T Flint</creatorcontrib><creatorcontrib>Graves, Steven W</creatorcontrib><title>Serum biomarkers predictive of pre-eclampsia</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>We sought serum biomarkers predictive of pre-eclampsia (PE).
: Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach.
Many statistically significant serum PE biomarker candidates (n > 60) were found comparing cases and controls. In addition, logistic regression analysis modeled biomarker data resulted in 14 different multimarker combinations having high detection sensitivity and specificity (AUC >0.9).
Developed panels of serum biomarkers appeared effective in identifying pregnant women at 12-14 weeks gestation at risk of PE later in their pregnancy.</description><subject>Adult</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Blood Proteins - metabolism</subject><subject>Diagnosis</subject><subject>early diagnosis</subject><subject>Female</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Identification and classification</subject><subject>Lipids</subject><subject>Mass spectrometry</subject><subject>Methods</subject><subject>Molecular weight</subject><subject>Obstetrics</subject><subject>pre-eclampsia</subject><subject>Pre-Eclampsia - blood</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Proteomics - methods</subject><subject>Scientific imaging</subject><subject>Sensitivity and Specificity</subject><subject>serum proteomics</subject><subject>Studies</subject><subject>Womens health</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNptkV2L1TAQhoMo7ode-AfkgDcK9phJ2nxcLouuwoIX6nVIpxPJ2rTHpBX896aedVFZ5iKZ4Zl3hnkZewZ8LwToN31Ke-j2Ah6wU9CdaLjU8PDur-QJOyvlhvNOayUesxOhuLZWwSl7_YnymnZ9nJPP3yiX3SHTEHGJP2g3hy1rCEefDiX6J-xR8GOhp7fvOfvy7u3ny_fN9cerD5cX1w22Vi2N9oPkppedHTj2XqMAUjKoQRscBpS2VaCxNRja3qIFr2sgyU5qE4IGec5eHnUPef6-UllcigVpHP1E81ocKGNNC8BNRV_8h97Ma57qdr8pYQ2Yv6ivfiQXpzAv2eMm6i5aMMArto3d30PVGChFnCcKsdb_aXh1bMA8l5IpuEOO9Y4_HXC3OeOqMw46Jzb2-e2ia59ouCP_WFGB7giEdVkzFYw0IbljljZP4kT3CP8CXvyYug</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Anand, Swati</creator><creator>Bench Alvarez, Tanielle Mei</creator><creator>Johnson, W Evan</creator><creator>Esplin, M Sean</creator><creator>Merrell, Karen</creator><creator>Porter, T Flint</creator><creator>Graves, Steven W</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Serum biomarkers predictive of pre-eclampsia</title><author>Anand, Swati ; Bench Alvarez, Tanielle Mei ; Johnson, W Evan ; Esplin, M Sean ; Merrell, Karen ; Porter, T Flint ; Graves, Steven W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-7ad308b359d0cba7c21e63f6d78cddc394617c48cf4b9c91a7a7ace35378ff713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood pressure</topic><topic>Blood Proteins - metabolism</topic><topic>Diagnosis</topic><topic>early diagnosis</topic><topic>Female</topic><topic>Gynecology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Identification and classification</topic><topic>Lipids</topic><topic>Mass spectrometry</topic><topic>Methods</topic><topic>Molecular weight</topic><topic>Obstetrics</topic><topic>pre-eclampsia</topic><topic>Pre-Eclampsia - blood</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Proteomics - methods</topic><topic>Scientific imaging</topic><topic>Sensitivity and Specificity</topic><topic>serum proteomics</topic><topic>Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anand, Swati</creatorcontrib><creatorcontrib>Bench Alvarez, Tanielle Mei</creatorcontrib><creatorcontrib>Johnson, W Evan</creatorcontrib><creatorcontrib>Esplin, M Sean</creatorcontrib><creatorcontrib>Merrell, Karen</creatorcontrib><creatorcontrib>Porter, T Flint</creatorcontrib><creatorcontrib>Graves, Steven W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anand, Swati</au><au>Bench Alvarez, Tanielle Mei</au><au>Johnson, W Evan</au><au>Esplin, M Sean</au><au>Merrell, Karen</au><au>Porter, T Flint</au><au>Graves, Steven W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum biomarkers predictive of pre-eclampsia</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>9</volume><issue>6</issue><spage>563</spage><epage>575</epage><pages>563-575</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>We sought serum biomarkers predictive of pre-eclampsia (PE).
: Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach.
Many statistically significant serum PE biomarker candidates (n > 60) were found comparing cases and controls. In addition, logistic regression analysis modeled biomarker data resulted in 14 different multimarker combinations having high detection sensitivity and specificity (AUC >0.9).
Developed panels of serum biomarkers appeared effective in identifying pregnant women at 12-14 weeks gestation at risk of PE later in their pregnancy.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>26079961</pmid><doi>10.2217/bmm.15.21</doi><tpages>13</tpages></addata></record> |
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| identifier | ISSN: 1752-0363 |
| ispartof | Biomarkers in medicine, 2015-06, Vol.9 (6), p.563-575 |
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| source | PubMed (Medline) |
| subjects | Adult Biological markers Biomarkers Biomarkers - blood Blood pressure Blood Proteins - metabolism Diagnosis early diagnosis Female Gynecology Humans Hypertension Identification and classification Lipids Mass spectrometry Methods Molecular weight Obstetrics pre-eclampsia Pre-Eclampsia - blood Preeclampsia Pregnancy Proteins Proteomics - methods Scientific imaging Sensitivity and Specificity serum proteomics Studies Womens health |
| title | Serum biomarkers predictive of pre-eclampsia |
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