Deproteinized bovine bone in association with guided tissue regeneration or enamel matrix derivatives procedures in aggressive periodontitis patients: a 1-year retrospective study

• Published in: Journal of clinical periodontology 2015-06, Vol.42 (6), p.547-556
• Main Authors: Artzi, Zvi, Tal, Haim, Platner, Ori, Wasersprung, Nadav, Weinberg, Evgeny, Slutzkey, Shimshon, Gozali, Nir, Carmeli, Guy, Herzberg, Ran, Kozlovsky, Avital
• Format: Article
• Language: English
• Subjects: Absorbable Implants; Adolescent; Adult; Aggressive periodontitis; Aggressive Periodontitis - drug therapy; Aggressive Periodontitis - surgery; Alveolar Bone Loss - drug therapy; Alveolar Bone Loss - surgery; Animals; Bone Transplantation - methods; Cattle; Cohort Studies; Dental Enamel Proteins - therapeutic use; Dentistry; deproteinized bovine bone (Bio-Oss®); enamel matrix derivatives (Emdogain®); Female; Follow-Up Studies; Gingival Recession - drug therapy; Gingival Recession - surgery; guided tissue regeneration; Guided Tissue Regeneration, Periodontal - methods; Heterografts - transplantation; Humans; Male; Membranes, Artificial; Periodontal Attachment Loss - drug therapy; Periodontal Attachment Loss - surgery; Periodontal Pocket - drug therapy; Periodontal Pocket - surgery; periodontal regeneration; Retrospective Studies; Treatment Outcome; Young Adult
• ISSN: 0303-6979; 1600-051X
• DOI: 10.1111/jcpe.12413

Objectives To retrospectively evaluate and compare two regenerative periodontal procedures in young individuals with aggressive periodontitis (AgP). Methods Thirty‐two patients aged 14–25 years (mean ± SD 19.3 ± 5.7) were diagnosed as having AgP with multiple intra‐bony defects (IBDs) and treated by one of two regenerative modalities of periodontal therapy: guided tissue regeneration (GTR) using deproteinized bone xenograft (DBX) particles and a resorbable membrane (the GTR group), or an application of enamel matrix derivatives (EMD) combined with DBX (the EMD/DBX group). Periodic monitoring of treated sites included recording of probing depth (PD), clinical attachment level (CAL) and gingival recession. Pre‐treatment and 1‐year post‐operative findings were statistically analysed within and between groups. Results The PD and CAL values decreased significantly with time, but not those between study groups. The mean pre‐treatment and 1‐year post‐treatment PDs of the IBDs of the GTR group (n = 16; sites = 67) were 8.93 ± 1.14 mm and 3.58 ± 0.50 mm, respectively, and the mean CALs were 9.03 ± 1.03 mm and 4.16 ± 0.53 mm respectively. The mean PDs of the EMD/DBX group (n = 16; sites = 73) were 8.77 ± 1.04 mm and 3.61 ± 0.36 mm, respectively, and the mean CALS were 8.79 ± 1.04 mm and 3.77 ± 0.22 mm respectively (p