Removal of cytokines from HSA-containing solutions by adsorption onto silica

Septic shock syndrome is a potentially fatal medical condition that is associated with elevated blood levels of low molecular weight proteins know as cytokines. The removal of cytokines from the blood by adsorption into silica was investigated. Results showed that increased concentrations of NaCl re...

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Bibliographic Details
Published in:Biotechnology and bioengineering 1994, Vol.44 (9), p.1023-1030
Main Authors: HEI, H. J, ELKALAY, M. A, LIN, A. T. T, KSHIRSAGAR, B, OKARMA, T. B, BLANCH, H. W
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Others
Various methods and equipments
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Summary:Septic shock syndrome is a potentially fatal medical condition that is associated with elevated blood levels of low molecular weight proteins know as cytokines. The removal of cytokines from the blood by adsorption into silica was investigated. Results showed that increased concentrations of NaCl reduced cyotokine adsorption but did not completely eliminate absorption even at high concentrations, suggesting that adsorption was not entirely electrostatic in nature.
ISSN:0006-3592
1097-0290