Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology: a possible involvement of local immune reactions

Highlights • We provide the pathological features of the myometrium in postpartum hemorrhage (PPH) of unknown etiology. • Massive infiltration of inflammatory and immune cells is significant in myometrium of PPH. • Postpartum acute myometritis (PAM) could be a pathological concept of PPH of unknown...

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Bibliographic Details
Published in:Journal of reproductive immunology 2015-08, Vol.110, p.74-80
Main Authors: Farhana, Mustari, Tamura, Naoaki, Mukai, Mari, Ikuma, Kotomi, Koumura, Yukiko, Furuta, Naomi, Yaguchi, Chizuko, Uchida, Toshiyuki, Suzuki, Kazunao, Sugihara, Kazuhiro, Itoh, Hiroaki, Kanayama, Naohiro
Format: Article
Language:English
Subjects:
Adult
Amniotic fluid embolism
Antigens, CD - immunology
Complement Activation
Female
Humans
Immunohistochemistry
Myometritis
Myometrium - immunology
Myometrium - pathology
Obstetrics and Gynecology
Postpartum hemorrhage (PPH)
Postpartum Hemorrhage - immunology
Postpartum Hemorrhage - pathology
Pregnancy
Uterine atony
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Summary:Highlights • We provide the pathological features of the myometrium in postpartum hemorrhage (PPH) of unknown etiology. • Massive infiltration of inflammatory and immune cells is significant in myometrium of PPH. • Postpartum acute myometritis (PAM) could be a pathological concept of PPH of unknown etiology. • Fetal components are a major candidate for the causes of PAM.
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2015.04.004