Glomerular haemodynamic profile of patients with Type 1 diabetes compared with healthy control subjects

• Published in: Diabetic medicine 2015-07, Vol.32 (7), p.972-979
• Main Authors: Škrtić, M., Lytvyn, Y., Yang, G. K., Yip, P., Lai, V., Silverman, M., Cherney, D. Z. I.
• Format: Article
• Language: English
• Subjects: Adult; Afferent Pathways - physiopathology; Algorithms; Arterioles - innervation; Arterioles - physiopathology; Cohort Studies; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetic Nephropathies - physiopathology; Efferent Pathways - physiopathology; Female; Glomerular Filtration Barrier - blood supply; Glomerular Filtration Barrier - innervation; Glomerular Filtration Barrier - physiopathology; Glomerular Filtration Rate; Glomerulonephritis - complications; Glomerulonephritis - physiopathology; Glucose Clamp Technique; Humans; Hyperglycemia - physiopathology; Hyperglycemia - prevention & control; Kidney Glomerulus - blood supply; Kidney Glomerulus - innervation; Kidney Glomerulus - physiopathology; Male; Renal Circulation; Vascular Resistance; Young Adult
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/dme.12717

Aims To evaluate the glomerular haemodynamic profile of patients with Type 1 diabetes with either renal hyperfiltration (GFR ≥ 135 ml/min/1.73 m2) or renal normofiltration (GFR 90–134 ml/min/1.73 m2) during euglycaemic and hyperglycaemic conditions, and to compare this profile with that of a similar group of healthy control subjects. Methods Gomez's equations were used to derive afferent and efferent arteriolar resistances, glomerular hydrostatic pressure and filtration pressure. Results At baseline, during clamped euglycaemia, patients with Type 1 diabetes and hyperfiltration had lower mean ± sd afferent arteriolar resistance than both those with Type 1 diabetes and normofiltration (914 ± 494 vs. 2065 ± 597 dyne/s/cm5; P