Synthesis of (+)-Antroquinonol: An Antihyperglycemic Agent

The total synthesis of antroquinonol has been accomplished through Suzuki–Miyaura cross-coupling and Barton–McCombie reaction, and the α,β-unsaturation was achieved through selenylation and oxidation protocols. In vitro and in vivo studies on the glucose-lowering properties of antroquinonol indicate...

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Bibliographic Details
Published in:Journal of organic chemistry 2015-06, Vol.80 (12), p.6044-6051
Main Authors: Sulake, Rohidas S, Lin, Hsiao-Han, Hsu, Chia-Yu, Weng, Ching-Feng, Chen, Chinpiao
Format: Article
Language:English
Subjects:
Hypoglycemic Agents - chemical synthesis
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Oxidation-Reduction
Ubiquinone - analogs & derivatives
Ubiquinone - chemical synthesis
Ubiquinone - chemistry
Ubiquinone - pharmacology
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Summary:The total synthesis of antroquinonol has been accomplished through Suzuki–Miyaura cross-coupling and Barton–McCombie reaction, and the α,β-unsaturation was achieved through selenylation and oxidation protocols. In vitro and in vivo studies on the glucose-lowering properties of antroquinonol indicate that it is a potential antidiabetic agent.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b00345