Lymph Node Harvest During Esophagectomy Is Not Influenced by Use of Neoadjuvant Therapy or Clinical Disease Stage

Introduction The purpose of this study was to evaluate the effects of neoadjuvant therapy on lymph node harvest (LNH), lymph node ratio (LNR), and overall survival rates after esophagectomy. Methods A retrospective analysis of 111 patients who underwent esophagectomy for esophageal adenocarcinoma fr...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2015-07, Vol.19 (7), p.1201-1207
Main Authors: Luna, Renato A., Dolan, James P., Diggs, Brian S., Bronson, Nathan W., Sheppard, Brett C., Schipper, Paul H., Tieu, Brandon H., Feeney, Benjamin T., Gatter, Ken M., Vaccaro, Gina M., Thomas, Charles R., Hunter, John G.
Format: Article
Language:English
Subjects:
Abdomen
Adenocarcinoma
Aged
Cancer therapies
Chemoradiotherapy, Adjuvant
Esophageal cancer
Esophageal Neoplasms - pathology
Esophageal Neoplasms - therapy
Esophagectomy
Female
Gastroenterology
Humans
Induction therapy
Lymph Node Excision
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic system
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Original Article
Ostomy
Radiation
Retrospective Studies
Science
Surgery
Survival Rate
Thoracic surgery
Tomography
Treatment Outcome
Veins & arteries
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Summary:Introduction The purpose of this study was to evaluate the effects of neoadjuvant therapy on lymph node harvest (LNH), lymph node ratio (LNR), and overall survival rates after esophagectomy. Methods A retrospective analysis of 111 patients who underwent esophagectomy for esophageal adenocarcinoma from 2001 to 2010 was performed. Patients were divided into two groups: neoadjuvant chemoradiotherapy prior to surgery (NEOSURG) versus surgery alone (SURG). Results There were 83 patients (75 %) in the NEOSURG group and 28 (25 %) in the SURG group with a mean age of 66 and 67 years, respectively. The median LNH in the NEOSURG group and SURG group was 16.0 and 15.5, respectively ( p  = 0.57). Within the NEOSURG group, the median LNH was 16 for complete responders, 14 for partial responders, 16 for nonresponders, and 18 in those who were pathologically upstaged ( p  = 0.434). The median LNR was 0, 0, 0.1, and 0.2, respectively ( p  
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-015-2821-4