Edoxaban, a Novel Oral Factor Xa Inhibitor

• Published in: The Annals of pharmacotherapy 2015-07, Vol.49 (7), p.843-850
• Main Authors: Minor, Chelsea, Tellor, Katie B., Armbruster, Anastasia L.
• Format: Article
• Language: English
• Subjects: Atrial Fibrillation - drug therapy; Drug Interactions; Factor Xa Inhibitors - pharmacology; Factor Xa Inhibitors - therapeutic use; Hemorrhage - chemically induced; Humans; Pyridines - pharmacology; Pyridines - therapeutic use; Randomized Controlled Trials as Topic; Stroke - prevention & control; Thiazoles - pharmacology; Thiazoles - therapeutic use; Venous Thromboembolism - drug therapy
• ISSN: 1060-0280; 1542-6270
• DOI: 10.1177/1060028015579426

Objective: To evaluate the current literature and potential clinical role of edoxaban (Savaysa) for stroke prevention in nonvalvular atrial fibrillation (NVAF) and treatment of deep-vein thrombosis and pulmonary embolism. Data Sources: A PubMed and Cochrane Central Register of Controlled trials search was conducted in February2015 using the search terms edoxaban (ordu-176b) and atrial fibrillation, deep vein thrombosis, pulmonary embolism, or venous thromboembolism. Bibliographies of all retrieved articles were reviewed. All references included were published between 1998 and 2015. Study Selection/Data Extraction: All studies that included humans and contained data describing the use of edoxaban for either stroke prevention in patients with NVAF or the treatment of venous thromboembolism (VTE) were reviewed. Data Synthesis: Edoxaban is a target-specific oral anticoagulant, specifically a factor Xa inhibitor. It has been studied in 4 major randomized controlled trials for the prevention of stroke and systemic embolism in patients with NVAF. One randomized controlled trial was conducted for the treatment of VTE. Edoxaban demonstrated noninferiority of the primary efficacy end point compared with warfarin for both approved indications. The most common adverse effect is bleeding, similar to other anticoagulants. A dosing limitation exists related to patients treated for NVAF with creatinine clearance >95 mL/min; these patients experienced decreased efficacy. Conclusions: Edoxaban is a safe and effective anticoagulant to reduce the risk of stroke in patients with NVAF and for the treatment of VTE.