Antinuclear Antibodies Are Associated With All-Cause Mortality and Cardiovascular Outcomes in the General Population

Associations of log-transformed ANA with all-cause mortality, cardiovascular death, and ASCVD were assessed by Cox proportional hazards regression, adjusting for: 1) age, race/ethnicity, and sex; and 2) model 1 plus hypertension, diabetes, smoking, body mass index, estimated glomerular filtration ra...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-06, Vol.65 (24), p.2669-2670
Main Authors: Solow, Elizabeth Blair, MD, Vongpatanasin, Wanpen, MD, Skaug, Brian, MD, Karp, David R., MD, PhD, Ayers, Colby, MS, de Lemos, James A., MD
Format: Article
Language:English
Subjects:
Antibodies, Antinuclear - blood
Autoimmune diseases
Biomarkers - blood
Cardiology
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - mortality
Cholesterol
Cohort Studies
Confidence intervals
Diabetes
Enzymes
Ethnicity
Female
Health risk assessment
Heart attacks
Humans
Hypertension
Internal Medicine
Male
Mortality
Mortality - trends
Population
Population Surveillance - methods
Risk factors
Treatment Outcome
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Summary:Associations of log-transformed ANA with all-cause mortality, cardiovascular death, and ASCVD were assessed by Cox proportional hazards regression, adjusting for: 1) age, race/ethnicity, and sex; and 2) model 1 plus hypertension, diabetes, smoking, body mass index, estimated glomerular filtration rate, statin use, total cholesterol, triglycerides, and high-density lipoprotein cholesterol. [...]increasing ANA are independently associated with all-cause mortality, cardiovascular death, and ASCVD in a representative multiethnic population-based cohort.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.03.578