Detection of boronic acid derivatives in cells using a fluorescent sensor

The detection of boron-containing compounds requires very expensive facilities and/or tedious sample pretreatments. In an effort to develop a convenient detection method for boronic acid derivatives, boron chelating-ligands were synthesized for use as fluorescent sensors. In this paper, the synthesi...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2015-07, Vol.13 (25), p.6927-6930
Main Authors: Hattori, Yoshihide, Ishimura, Miki, Ohta, Youichirou, Takenaka, Hiroshi, Watanabe, Tsubasa, Tanaka, Hiroki, Ono, Koji, Kirihata, Mitsunori
Format: Article
Language:English
Subjects:
Antineoplastic Agents - analysis
Boron - chemistry
Boron Compounds - analysis
Boronic Acids - analysis
Bortezomib - analysis
Cell Line, Tumor
Chelating Agents - chemistry
Fluorescent Dyes - chemistry
Humans
Optical Imaging - methods
Phenylalanine - analogs & derivatives
Phenylalanine - analysis
Spectrometry, Fluorescence - methods
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Summary:The detection of boron-containing compounds requires very expensive facilities and/or tedious sample pretreatments. In an effort to develop a convenient detection method for boronic acid derivatives, boron chelating-ligands were synthesized for use as fluorescent sensors. In this paper, the synthesis and properties of fluorescent sensors for boronic acid derivatives are reported.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00753d