Verneuil's disease, innate immunity and vitamin D: a pilot study

Background Verneuil's disease is a chronic inflammatory skin disease of the follicles in apocrine glands rich area of the skin (axillary, inguinal, anogenital) and is associated with a deficient skin innate immunity. It is characterized by the occurrence of nodules, abscesses, fistulas, scars....

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Published in:Journal of the European Academy of Dermatology and Venereology 2015-07, Vol.29 (7), p.1347-1353
Main Authors: Guillet, A., Brocard, A., Bach Ngohou, K., Graveline, N., Leloup, A.-G., Ali, D., Nguyen, J.-M., Loirat, M.-J., Chevalier, C., Khammari, A., Dreno, B.
Format: Article
Language:English
Subjects:
Adult
Apocrine Glands - pathology
Calcifediol - blood
Dietary Supplements
Dose-Response Relationship, Drug
Female
Hidradenitis Suppurativa - drug therapy
Hidradenitis Suppurativa - etiology
Hidradenitis Suppurativa - immunology
Humans
Immunity, Innate
Male
Middle Aged
Pilot Projects
Vitamin D - administration & dosage
Vitamin D Deficiency - complications
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - immunology
Vitamins - administration & dosage
Young Adult
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Summary:Background Verneuil's disease is a chronic inflammatory skin disease of the follicles in apocrine glands rich area of the skin (axillary, inguinal, anogenital) and is associated with a deficient skin innate immunity. It is characterized by the occurrence of nodules, abscesses, fistulas, scars. Recently, vitamin D has been shown to stimulate skin innate immunity. Objective The primary objective of the study was to assess whether Verneuil's disease was associated with vitamin D deficiency. The secondary objective was to determine whether vitamin D supplementation could improve inflammatory lesions. Methods First, 25(OH) vitamin D3 serum levels in patients with Verneuil's disease followed at Nantes University Hospital were compared to those of healthy donors from the French Blood Bank. Then, a pilot study was conducted in 14 patients supplemented with vitamin D according to their vitamin D level at baseline at months 3 and 6. The endpoints at 6 months were decreased by at least 20% in the number of nodules and in the frequency of flare‐ups. Results Twenty‐two patients (100%) had vitamin D deficiency (level
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.12857