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Verneuil's disease, innate immunity and vitamin D: a pilot study
Background Verneuil's disease is a chronic inflammatory skin disease of the follicles in apocrine glands rich area of the skin (axillary, inguinal, anogenital) and is associated with a deficient skin innate immunity. It is characterized by the occurrence of nodules, abscesses, fistulas, scars....
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| Published in: | Journal of the European Academy of Dermatology and Venereology 2015-07, Vol.29 (7), p.1347-1353 |
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| container_title | Journal of the European Academy of Dermatology and Venereology |
| container_volume | 29 |
| creator | Guillet, A. Brocard, A. Bach Ngohou, K. Graveline, N. Leloup, A.-G. Ali, D. Nguyen, J.-M. Loirat, M.-J. Chevalier, C. Khammari, A. Dreno, B. |
| description | Background
Verneuil's disease is a chronic inflammatory skin disease of the follicles in apocrine glands rich area of the skin (axillary, inguinal, anogenital) and is associated with a deficient skin innate immunity. It is characterized by the occurrence of nodules, abscesses, fistulas, scars. Recently, vitamin D has been shown to stimulate skin innate immunity.
Objective
The primary objective of the study was to assess whether Verneuil's disease was associated with vitamin D deficiency. The secondary objective was to determine whether vitamin D supplementation could improve inflammatory lesions.
Methods
First, 25(OH) vitamin D3 serum levels in patients with Verneuil's disease followed at Nantes University Hospital were compared to those of healthy donors from the French Blood Bank. Then, a pilot study was conducted in 14 patients supplemented with vitamin D according to their vitamin D level at baseline at months 3 and 6. The endpoints at 6 months were decreased by at least 20% in the number of nodules and in the frequency of flare‐ups.
Results
Twenty‐two patients (100%) had vitamin D deficiency (level |
| doi_str_mv | 10.1111/jdv.12857 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1690649784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1690649784</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3637-24985a6f355037b402d29dbe47faa7a9c92127e7bec844bd2db181891f53b73f3</originalsourceid><addsrcrecordid>eNp1kDtPwzAURi0EouUx8AeQN0Ai4GdsM4EKFFBVpAqKxGI5sSMZkrTESSH_nkBLN-5yl_Od4QBwgNEZ7u78zS7OMJFcbIA-ZrGMKJJ0E_SRInGkFFc9sBPCG0IIYy63QY9wjgmSrA8up64qXePzowCtD84Edwp9WZraQV8UTenrFprSwoWvTeFLeH0BDZz7fFbDUDe23QNbmcmD21_9XfB8e_M0uItGj8P7wdUoSmlMRUSYktzEGeUcUZEwRCxRNnFMZMYIo1JFMBFOJC6VjCWW2ARLLBXOOE0EzeguOF5659Xso3Gh1oUPqctzU7pZEzSOFYqZEpJ16MkSTatZCJXL9LzyhalajZH-Caa7YPo3WMcerrRNUji7Jv8KdcD5Evj0uWv_N-mH6-mfMloufKjd13phqncdCyq4fhkP9WQsXycvr0rf0W_V0IKu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1690649784</pqid></control><display><type>article</type><title>Verneuil's disease, innate immunity and vitamin D: a pilot study</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Guillet, A. ; Brocard, A. ; Bach Ngohou, K. ; Graveline, N. ; Leloup, A.-G. ; Ali, D. ; Nguyen, J.-M. ; Loirat, M.-J. ; Chevalier, C. ; Khammari, A. ; Dreno, B.</creator><creatorcontrib>Guillet, A. ; Brocard, A. ; Bach Ngohou, K. ; Graveline, N. ; Leloup, A.-G. ; Ali, D. ; Nguyen, J.-M. ; Loirat, M.-J. ; Chevalier, C. ; Khammari, A. ; Dreno, B.</creatorcontrib><description>Background
Verneuil's disease is a chronic inflammatory skin disease of the follicles in apocrine glands rich area of the skin (axillary, inguinal, anogenital) and is associated with a deficient skin innate immunity. It is characterized by the occurrence of nodules, abscesses, fistulas, scars. Recently, vitamin D has been shown to stimulate skin innate immunity.
Objective
The primary objective of the study was to assess whether Verneuil's disease was associated with vitamin D deficiency. The secondary objective was to determine whether vitamin D supplementation could improve inflammatory lesions.
Methods
First, 25(OH) vitamin D3 serum levels in patients with Verneuil's disease followed at Nantes University Hospital were compared to those of healthy donors from the French Blood Bank. Then, a pilot study was conducted in 14 patients supplemented with vitamin D according to their vitamin D level at baseline at months 3 and 6. The endpoints at 6 months were decreased by at least 20% in the number of nodules and in the frequency of flare‐ups.
Results
Twenty‐two patients (100%) had vitamin D deficiency (level <30 ng/mL) of whom 36% were severely deficient (level <10 ng/mL), having correlation with the disease severity (P = 0.03268) vs. 20 controls with vitamin D deficiency (91%) of whom 14% were severely deficient. In 14 patients, the supplementation significantly decreased the number of nodules at 6 months (P = 0.01133), and the endpoints were achieved in 79% of these patients. A correlation between the therapeutic success and the importance of the increase in vitamin D level after supplementation was observed (P = 0.01099).
Conclusion
Our study shows that Verneuil's disease is associated with a major vitamin D deficiency, correlated with the disease severity. It suggests that vitamin D could significantly improve the inflammatory nodules, probably by stimulating the skin innate immunity. A larger randomized study is needed to confirm these findings.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/jdv.12857</identifier><identifier>PMID: 25512084</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Apocrine Glands - pathology ; Calcifediol - blood ; Dietary Supplements ; Dose-Response Relationship, Drug ; Female ; Hidradenitis Suppurativa - drug therapy ; Hidradenitis Suppurativa - etiology ; Hidradenitis Suppurativa - immunology ; Humans ; Immunity, Innate ; Male ; Middle Aged ; Pilot Projects ; Vitamin D - administration & dosage ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - drug therapy ; Vitamin D Deficiency - immunology ; Vitamins - administration & dosage ; Young Adult</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2015-07, Vol.29 (7), p.1347-1353</ispartof><rights>2014 European Academy of Dermatology and Venereology</rights><rights>2014 European Academy of Dermatology and Venereology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3637-24985a6f355037b402d29dbe47faa7a9c92127e7bec844bd2db181891f53b73f3</citedby><cites>FETCH-LOGICAL-c3637-24985a6f355037b402d29dbe47faa7a9c92127e7bec844bd2db181891f53b73f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25512084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guillet, A.</creatorcontrib><creatorcontrib>Brocard, A.</creatorcontrib><creatorcontrib>Bach Ngohou, K.</creatorcontrib><creatorcontrib>Graveline, N.</creatorcontrib><creatorcontrib>Leloup, A.-G.</creatorcontrib><creatorcontrib>Ali, D.</creatorcontrib><creatorcontrib>Nguyen, J.-M.</creatorcontrib><creatorcontrib>Loirat, M.-J.</creatorcontrib><creatorcontrib>Chevalier, C.</creatorcontrib><creatorcontrib>Khammari, A.</creatorcontrib><creatorcontrib>Dreno, B.</creatorcontrib><title>Verneuil's disease, innate immunity and vitamin D: a pilot study</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background
Verneuil's disease is a chronic inflammatory skin disease of the follicles in apocrine glands rich area of the skin (axillary, inguinal, anogenital) and is associated with a deficient skin innate immunity. It is characterized by the occurrence of nodules, abscesses, fistulas, scars. Recently, vitamin D has been shown to stimulate skin innate immunity.
Objective
The primary objective of the study was to assess whether Verneuil's disease was associated with vitamin D deficiency. The secondary objective was to determine whether vitamin D supplementation could improve inflammatory lesions.
Methods
First, 25(OH) vitamin D3 serum levels in patients with Verneuil's disease followed at Nantes University Hospital were compared to those of healthy donors from the French Blood Bank. Then, a pilot study was conducted in 14 patients supplemented with vitamin D according to their vitamin D level at baseline at months 3 and 6. The endpoints at 6 months were decreased by at least 20% in the number of nodules and in the frequency of flare‐ups.
Results
Twenty‐two patients (100%) had vitamin D deficiency (level <30 ng/mL) of whom 36% were severely deficient (level <10 ng/mL), having correlation with the disease severity (P = 0.03268) vs. 20 controls with vitamin D deficiency (91%) of whom 14% were severely deficient. In 14 patients, the supplementation significantly decreased the number of nodules at 6 months (P = 0.01133), and the endpoints were achieved in 79% of these patients. A correlation between the therapeutic success and the importance of the increase in vitamin D level after supplementation was observed (P = 0.01099).
Conclusion
Our study shows that Verneuil's disease is associated with a major vitamin D deficiency, correlated with the disease severity. It suggests that vitamin D could significantly improve the inflammatory nodules, probably by stimulating the skin innate immunity. A larger randomized study is needed to confirm these findings.</description><subject>Adult</subject><subject>Apocrine Glands - pathology</subject><subject>Calcifediol - blood</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Hidradenitis Suppurativa - drug therapy</subject><subject>Hidradenitis Suppurativa - etiology</subject><subject>Hidradenitis Suppurativa - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - drug therapy</subject><subject>Vitamin D Deficiency - immunology</subject><subject>Vitamins - administration & dosage</subject><subject>Young Adult</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kDtPwzAURi0EouUx8AeQN0Ai4GdsM4EKFFBVpAqKxGI5sSMZkrTESSH_nkBLN-5yl_Od4QBwgNEZ7u78zS7OMJFcbIA-ZrGMKJJ0E_SRInGkFFc9sBPCG0IIYy63QY9wjgmSrA8up64qXePzowCtD84Edwp9WZraQV8UTenrFprSwoWvTeFLeH0BDZz7fFbDUDe23QNbmcmD21_9XfB8e_M0uItGj8P7wdUoSmlMRUSYktzEGeUcUZEwRCxRNnFMZMYIo1JFMBFOJC6VjCWW2ARLLBXOOE0EzeguOF5659Xso3Gh1oUPqctzU7pZEzSOFYqZEpJ16MkSTatZCJXL9LzyhalajZH-Caa7YPo3WMcerrRNUji7Jv8KdcD5Evj0uWv_N-mH6-mfMloufKjd13phqncdCyq4fhkP9WQsXycvr0rf0W_V0IKu</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Guillet, A.</creator><creator>Brocard, A.</creator><creator>Bach Ngohou, K.</creator><creator>Graveline, N.</creator><creator>Leloup, A.-G.</creator><creator>Ali, D.</creator><creator>Nguyen, J.-M.</creator><creator>Loirat, M.-J.</creator><creator>Chevalier, C.</creator><creator>Khammari, A.</creator><creator>Dreno, B.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201507</creationdate><title>Verneuil's disease, innate immunity and vitamin D: a pilot study</title><author>Guillet, A. ; Brocard, A. ; Bach Ngohou, K. ; Graveline, N. ; Leloup, A.-G. ; Ali, D. ; Nguyen, J.-M. ; Loirat, M.-J. ; Chevalier, C. ; Khammari, A. ; Dreno, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3637-24985a6f355037b402d29dbe47faa7a9c92127e7bec844bd2db181891f53b73f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Apocrine Glands - pathology</topic><topic>Calcifediol - blood</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Hidradenitis Suppurativa - drug therapy</topic><topic>Hidradenitis Suppurativa - etiology</topic><topic>Hidradenitis Suppurativa - immunology</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - drug therapy</topic><topic>Vitamin D Deficiency - immunology</topic><topic>Vitamins - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guillet, A.</creatorcontrib><creatorcontrib>Brocard, A.</creatorcontrib><creatorcontrib>Bach Ngohou, K.</creatorcontrib><creatorcontrib>Graveline, N.</creatorcontrib><creatorcontrib>Leloup, A.-G.</creatorcontrib><creatorcontrib>Ali, D.</creatorcontrib><creatorcontrib>Nguyen, J.-M.</creatorcontrib><creatorcontrib>Loirat, M.-J.</creatorcontrib><creatorcontrib>Chevalier, C.</creatorcontrib><creatorcontrib>Khammari, A.</creatorcontrib><creatorcontrib>Dreno, B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guillet, A.</au><au>Brocard, A.</au><au>Bach Ngohou, K.</au><au>Graveline, N.</au><au>Leloup, A.-G.</au><au>Ali, D.</au><au>Nguyen, J.-M.</au><au>Loirat, M.-J.</au><au>Chevalier, C.</au><au>Khammari, A.</au><au>Dreno, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Verneuil's disease, innate immunity and vitamin D: a pilot study</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2015-07</date><risdate>2015</risdate><volume>29</volume><issue>7</issue><spage>1347</spage><epage>1353</epage><pages>1347-1353</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background
Verneuil's disease is a chronic inflammatory skin disease of the follicles in apocrine glands rich area of the skin (axillary, inguinal, anogenital) and is associated with a deficient skin innate immunity. It is characterized by the occurrence of nodules, abscesses, fistulas, scars. Recently, vitamin D has been shown to stimulate skin innate immunity.
Objective
The primary objective of the study was to assess whether Verneuil's disease was associated with vitamin D deficiency. The secondary objective was to determine whether vitamin D supplementation could improve inflammatory lesions.
Methods
First, 25(OH) vitamin D3 serum levels in patients with Verneuil's disease followed at Nantes University Hospital were compared to those of healthy donors from the French Blood Bank. Then, a pilot study was conducted in 14 patients supplemented with vitamin D according to their vitamin D level at baseline at months 3 and 6. The endpoints at 6 months were decreased by at least 20% in the number of nodules and in the frequency of flare‐ups.
Results
Twenty‐two patients (100%) had vitamin D deficiency (level <30 ng/mL) of whom 36% were severely deficient (level <10 ng/mL), having correlation with the disease severity (P = 0.03268) vs. 20 controls with vitamin D deficiency (91%) of whom 14% were severely deficient. In 14 patients, the supplementation significantly decreased the number of nodules at 6 months (P = 0.01133), and the endpoints were achieved in 79% of these patients. A correlation between the therapeutic success and the importance of the increase in vitamin D level after supplementation was observed (P = 0.01099).
Conclusion
Our study shows that Verneuil's disease is associated with a major vitamin D deficiency, correlated with the disease severity. It suggests that vitamin D could significantly improve the inflammatory nodules, probably by stimulating the skin innate immunity. A larger randomized study is needed to confirm these findings.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25512084</pmid><doi>10.1111/jdv.12857</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of the European Academy of Dermatology and Venereology, 2015-07, Vol.29 (7), p.1347-1353 |
| issn | 0926-9959 1468-3083 |
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| subjects | Adult Apocrine Glands - pathology Calcifediol - blood Dietary Supplements Dose-Response Relationship, Drug Female Hidradenitis Suppurativa - drug therapy Hidradenitis Suppurativa - etiology Hidradenitis Suppurativa - immunology Humans Immunity, Innate Male Middle Aged Pilot Projects Vitamin D - administration & dosage Vitamin D Deficiency - complications Vitamin D Deficiency - drug therapy Vitamin D Deficiency - immunology Vitamins - administration & dosage Young Adult |
| title | Verneuil's disease, innate immunity and vitamin D: a pilot study |
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